从免疫学角度看抗偏头痛药物。
Anti-migraine agents from an immunological point of view.
机构信息
Faculty of Applied Medical Sciences, Department of Medical Laboratory Technology, Immunology Group, King Abdul Aziz University, Jeddah, Saudi Arabia.
出版信息
J Transl Med. 2021 Jan 6;19(1):23. doi: 10.1186/s12967-020-02681-6.
Abstract
The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, while known as a potent vasodilator, is also a key neural and immune modulator. The roles of CGRP in immune determination, have been studied in depth, with particular focus on its functional significance with respect to common immune challenges i.e., bacterial, viral, fungal and parasitic infections. This review discusses many potential areas of concern in regard to blocking CGRP function and its potential influence on immune milieus during infection, and the risk of adverse effects. Finally, this review recommends specific measures to be taken into consideration when administering anti-CGRP/CGRPR agents.
摘要
新一代的抗偏头痛药物堪称我们对抗这种破坏性疾病的一个里程碑。然而，最近人们对这些药物的安全性表示担忧。降钙素基因相关肽（CGRP）不仅是一种有效的血管扩张剂，也是一种重要的神经和免疫调节剂。CGRP 在免疫调节中的作用已经得到了深入研究，特别是其在常见免疫挑战（如细菌、病毒、真菌和寄生虫感染）中的功能意义。本综述讨论了阻断 CGRP 功能及其在感染期间对免疫环境的潜在影响以及不良影响的风险等诸多潜在关注领域。最后，本综述建议在使用抗 CGRP/CGRPR 药物时应考虑采取具体措施。
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