Storm F K, Mahvi D M, Gilchrist K W
Department of Surgery, University of Wisconsin School of Medicine, Madison, USA.
J Surg Oncol. 1996 Jan;61(1):14-6. doi: 10.1002/(SICI)1096-9098(199601)61:1<14::AID-JSO4>3.0.CO;2-V.
Overexpression of heat shock protein 27 (hsp-27) is associated with reduced disease-free survival in early stage breast cancer. Histopathologic evidence of confluent necrosis within primary infiltrating ductal carcinoma (IDC) is similarly an indication of poor prognosis. We postulated that IDC evidencing confluent tumor necrosis (TN) might overexpress this protein, which would help explain why hsp-27 is associated with higher-risk cancers. To test this hypothesis, presence of TN (as opposed to individual cell apoptosis) and of hsp-27 expression by immunohistochemistry were evaluated independently in 48 specimens of IDC. Nineteen (40%) overexpressed hsp-27 and 10 (21%) displayed necrosis. IDCs with areas of TN are less likely to overexpress hsp-27, suggesting a lack of association between these histoprognostic variables. This negative correlation, however, supports hsp-27 as an independent predictor of high-risk disease.
热休克蛋白27（hsp - 27）的过表达与早期乳腺癌无病生存期缩短相关。原发性浸润性导管癌（IDC）内融合性坏死的组织病理学证据同样提示预后不良。我们推测，显示融合性肿瘤坏死（TN）的IDC可能会过表达这种蛋白，这将有助于解释为什么hsp - 27与高风险癌症相关。为了验证这一假设，我们在48例IDC标本中独立评估了TN（与单个细胞凋亡相对）的存在情况以及通过免疫组织化学检测的hsp - 27表达情况。19例（40%）过表达hsp - 27，10例（21%）显示坏死。存在TN区域的IDC过表达hsp - 27的可能性较小，提示这些组织预后变量之间缺乏关联。然而，这种负相关支持hsp - 27作为高风险疾病的独立预测指标。
