干扰素治疗后血清丙型肝炎病毒RNA清除情况与病毒基因型的关系

Clearance of serum hepatitis C virus RNA after interferon therapy in relation to virus genotype.

作者信息

Kanai K, Kako M, Aikawa T, Kumada T, Kawasaki T, Hatahara T, Oka Y, Mizokami M, Sakai T, Iwata K

机构信息

Department of Gastroenterology, Toshiba General Hospital, Tokyo, Japan.

出版信息

Liver. 1995 Aug;15(4):185-8. doi: 10.1111/j.1600-0676.1995.tb00668.x.

DOI:10.1111/j.1600-0676.1995.tb00668.x

PMID:8544640

Abstract

The effect of recombinant interferon-alfa on serum HCV RNA levels in Japanese patients with chronic hepatitis C was investigated. At 24 weeks of treatment, 41 (32.5%) of 126 patients lost HCV RNA from serum, and aminotransferases were normalized in 31 (75.6%) of these 41 cases. HCV genotypes were categorized into four types (Type I, II, III, IV); the frequencies among the patients were: Type I: 0%, Type II: 70.6%, Type III: 20.6%, and Type IV: 6.3%. At the end of the 24-week treatment, HCV RNA levels were remarkably decreased in Type III patients and became undetectable in 18 (69.2%) of 26. In contrast, only 18 (20.2%) of 89 patients with Type II and two of eight with Type IV lost HCV RNA from sera. The relation between HCV genotype (Type III) and response to IFN therapy was also confirmed using a logistic regression model. HCV genotype seems to be an important factor in determining the response to IFN in patients with chronic hepatitis C.

摘要

研究了重组干扰素-α对日本慢性丙型肝炎患者血清HCV RNA水平的影响。治疗24周时，126例患者中有41例（32.5%）血清中HCV RNA消失，这41例中的31例（75.6%）转氨酶恢复正常。HCV基因型分为四种类型（I型、II型、III型、IV型）；患者中的频率分别为：I型：0%，II型：70.6%，III型：20.6%，IV型：6.3%。在24周治疗结束时，III型患者的HCV RNA水平显著下降，26例中有18例（69.2%）变为检测不到。相比之下，89例II型患者中只有18例（20.2%）以及8例IV型患者中有2例血清中HCV RNA消失。使用逻辑回归模型也证实了HCV基因型（III型）与IFN治疗反应之间的关系。HCV基因型似乎是决定慢性丙型肝炎患者对IFN反应的一个重要因素。