黄酮类化合物对反复繁殖大鼠血小板黏附性的影响。
Effect of flavonoids on the platelet adhesiveness in repeatedly bred rats.
作者信息
Sempińska E, Kostka B, Królikowska M, Kalisiak E
出版信息
Pol J Pharmacol Pharm. 1977 Jan-Feb;29(1):7-10.
PMID:854480
Abstract
Decrease of the platelet adhesiveness in rats by some flavonoids has been stated using the method of glass wool filter. The antiadhesive activity of investigated flavonoids may be ordered as follows: nobiletin greater than isorhamnetin 5,7,4'-trimethylether 3-glucoside greater than isorhamnetin 3-glucoside. Methylation of hydroxyl groups of isorhamnetin-3-glucoside markedly increases its antiadhesive activity.
摘要
采用玻璃棉滤器法已表明某些黄酮类化合物可降低大鼠的血小板黏附性。所研究黄酮类化合物的抗黏附活性顺序如下：川陈皮素＞异鼠李素5,7,4'-三甲醚3-葡萄糖苷＞异鼠李素3-葡萄糖苷。异鼠李素-3-葡萄糖苷羟基的甲基化显著提高其抗黏附活性。
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