Algotsson A, Nordberg A, Almkvist O, Winblad B
Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden.
Neurobiol Aging. 1995 Jul-Aug;16(4):577-82. doi: 10.1016/0197-4580(95)00077-r.
Fifteen patients with Alzheimer's disease (AD) and 16 age-matched controls underwent skin vessel reactivity tests employing three vasodilating substances with different modes of action: acetylcholine (ACh), nitroprusside, and isoprenaline. The substances were iontophoresed into the skin and the results were mapped through a newly developed laser Doppler perfusion imager. The skin vascular responses of the patients to ACh and isoprenaline but not nitroprusside were significantly attenuated compared to those of the controls. The differences between patient and control groups concerning skin vessel reactivity might be due to receptor/signal transduction abnormalities but might in addition indicate an attenuated endothelium-dependent vasodilation in AD. The results of this study support the hypothesis that AD might be a systemic disease. They suggest that tests of skin vessel reactivity might be of help in the antemortem diagnosis of AD.
15名阿尔茨海默病（AD）患者和16名年龄匹配的对照者接受了皮肤血管反应性测试，使用了三种具有不同作用方式的血管扩张物质：乙酰胆碱（ACh）、硝普钠和异丙肾上腺素。这些物质通过离子电渗法导入皮肤，并通过新开发的激光多普勒灌注成像仪绘制结果。与对照组相比，患者对ACh和异丙肾上腺素而非硝普钠的皮肤血管反应明显减弱。患者组和对照组在皮肤血管反应性方面的差异可能是由于受体/信号转导异常，但也可能表明AD患者存在内皮依赖性血管舒张减弱。本研究结果支持AD可能是一种全身性疾病的假说。它们表明皮肤血管反应性测试可能有助于AD的生前诊断。
