Algotsson A, Nordberg A, Winblad B
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Sweden.
J Gerontol A Biol Sci Med Sci. 1995 Mar;50(2):M121-7. doi: 10.1093/gerona/50a.2.m121.
The aim of this study was to evaluate the influence of age and gender on skin vessel reactivity to one endothelium-dependent vasodilator (acetylcholine, ACh), and two endothelium-independent vasodilators with different modes of action (nitroprusside and isoprenaline).
The substances were iontophoresed into the skin and the results were mapped through a newly developed laser Doppler perfusion imager. Thirty-four healthy, nonsmoking individuals without any medication and without atopic constitution participated in the study. The subjects, 13 men and 21 women, 18 to 80 years of age, were divided into subgroups according to age and gender.
A correlation to age for the vascular responses to nitroprusside and, to a lesser extent, ACh was shown for the women (p = .0036 and .0920 respectively). Differences were also observed between the age and gender subgroups with respect to their response to these two substances: young and, to a lesser extent, middle-aged women differed from elderly women and middle-aged and elderly men. The response to isoprenaline was affected neither by age nor gender.
The results of the study suggest that skin vessel reactivity to nitroprusside and, to a lesser extent, ACh is age dependent. This might reflect both functional and structural changes in skin vasculature with aging. Gender differences for these two substances are also suggested, with women exhibiting a greater increase in perfusion after iontophoresis than men. However, higher vasoconstrictor tone among the women may have influenced the results.
本研究旨在评估年龄和性别对皮肤血管对一种内皮依赖性血管舒张剂（乙酰胆碱，ACh）以及两种作用方式不同的内皮非依赖性血管舒张剂（硝普钠和异丙肾上腺素）反应性的影响。
将这些物质通过离子导入法导入皮肤，并通过新开发的激光多普勒灌注成像仪绘制结果。34名健康、不吸烟、未服用任何药物且无特应性体质的个体参与了该研究。受试者包括13名男性和21名女性，年龄在18至80岁之间，根据年龄和性别分为亚组。
女性对硝普钠以及在较小程度上对ACh的血管反应与年龄存在相关性（分别为p = 0.0036和0.0920）。在年龄和性别亚组对这两种物质的反应方面也观察到差异：年轻女性以及在较小程度上中年女性与老年女性以及中年和老年男性不同。对异丙肾上腺素的反应既不受年龄也不受性别的影响。
研究结果表明，皮肤血管对硝普钠以及在较小程度上对ACh的反应性与年龄有关。这可能反映了随着年龄增长皮肤血管系统在功能和结构上的变化。还提示了这两种物质存在性别差异，女性在离子导入后灌注增加幅度大于男性。然而，女性较高的血管收缩张力可能影响了结果。
