Lephart E D
Department of Zoology, Brigham Young University, Provo, UT 84602, USA.
Neurobiol Aging. 1995 Jul-Aug;16(4):647-50. doi: 10.1016/0197-4580(95)98115-5.
Finasteride (Proscar), a 5 alpha-reductase inhibitor, was administered with or without 5 alpha-dihydrotestosterone (DHT) in juvenile (28), peripubertal (48), or young adult (68-day-old) male rats. Luteinizing hormone (LH) levels and ventral prostate (VP) weights monitored the efficacy of the treatments. For each postnatal day tested, LH hormone levels were not significantly altered by finasteride, suggesting that 5 alpha-reductase inhibition does not modulate LH in male rats using this protocol. Finasteride plus DHT treatment significantly decreased LH levels. Conversely, VP weights were significantly decreased in finasteride-treated animals while finasteride plus DHT treatment significantly increased VP values. Finasteride plus DHT treatment significantly decreased pituitary, but not brain, 5 alpha-reductase for each postnatal day tested. In finasteride-treated animals, hypothalamic and pituitary 5 alpha-reductase were significantly inhibited in young adult animals, whereas the activities were not altered in juvenile or peripubertal male rats. These data suggest that a different mechanism may regulate 5 alpha-reductase with the aging of the central nervous system and pituitary.
非那雄胺（保列治）是一种5α-还原酶抑制剂，在幼年（28日龄）、青春期前后（48日龄）或年轻成年（68日龄）雄性大鼠中，分别在给予或不给予5α-双氢睾酮（DHT）的情况下给药。通过监测黄体生成素（LH）水平和腹侧前列腺（VP）重量来评估治疗效果。对于所测试的每个出生后天数，非那雄胺对LH激素水平没有显著影响，这表明按照此方案，5α-还原酶抑制不会调节雄性大鼠的LH。非那雄胺加DHT治疗可显著降低LH水平。相反，非那雄胺治疗的动物VP重量显著降低，而非那雄胺加DHT治疗则显著增加VP值。对于所测试的每个出生后天数，非那雄胺加DHT治疗可显著降低垂体而非大脑的5α-还原酶。在非那雄胺治疗的动物中，年轻成年动物的下丘脑和垂体5α-还原酶受到显著抑制，而在幼年或青春期前后的雄性大鼠中，其活性未发生改变。这些数据表明，随着中枢神经系统和垂体的老化，可能存在不同的机制调节5α-还原酶。
