甲硫氨酸脑啡肽和阿片类拮抗剂对大鼠巨噬细胞的作用。

Effect of Met-enkephalin and opioid antagonists on rat macrophages.

作者信息

Radulović J, Dimitrijević M, Laban O, Stanojević S, Vasiljević T, Kovacević-Jovanović V, Marković B M

机构信息

Immunology Research Center, Branislav Janković, Belgrade, Yugoslavia.

出版信息

Peptides. 1995;16(7):1209-13. doi: 10.1016/0196-9781(95)02003-f.

DOI:10.1016/0196-9781(95)02003-f

PMID:8545240

Abstract

Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.

摘要

研究了甲硫氨酸脑啡肽（Met-ENK）和阿片类拮抗剂对DA和AO大鼠腹膜巨噬细胞释放过氧化氢（H2O2）的影响。Met-ENK分别增加和减少了DA和AO大鼠巨噬细胞的H2O2生成。低浓度而非高浓度的纳洛酮和ICI 174864可拮抗这些作用。两种拮抗剂的高浓度均直接调节H2O2释放，并保留了与Met-ENK相关的品系差异。结果表明，Met-ENK、纳洛酮和ICI 174864对大鼠巨噬细胞功能具有直接、品系和剂量依赖性的影响。