Kim C K, Pinel J P, Dalal S, Kippin T E, Kalynchuk L E, Payne G J
Department of Anatomy, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Pharmacol Biochem Behav. 1995 Nov;52(3):531-9. doi: 10.1016/0091-3057(95)00126-h.
The kindled-convulsion model of epilepsy was used to study contingent tolerance to ethanol's (1.5 g/kg; IP) anticonvulsant, hypothermic, and ataxic effects in adult male rats. In the present experiments, three groups of amygdala-kindled rats received a series of bidaily (one every 48 h) convulsive stimulations: one group received ethanol 1 h before each stimulation; one group received ethanol 1 h after each stimulation; and another group served as the saline control. Tolerance to ethanol's anticonvulsant effect (Experiments 1 and 2) was greatest in those rats that received ethanol before each convulsive stimulation; whereas, tolerance to ethanol's hypothermic (Experiments 1 and 2) and ataxic (Experiments 2) effects developed in both groups that received ethanol. These results were predicted on the basis of the drug-effect theory of drug tolerance: the theory that functional drug tolerance is an adaptation to the disruptive effects of drugs on concurrent patterns of neural activity, not to drug exposure per se.
采用癫痫点燃惊厥模型研究成年雄性大鼠对乙醇（1.5 g/kg；腹腔注射）抗惊厥、降温及共济失调作用的条件耐受性。在本实验中，三组杏仁核点燃大鼠接受一系列每两天一次（每48小时一次）的惊厥刺激：一组在每次刺激前1小时给予乙醇；一组在每次刺激后1小时给予乙醇；另一组作为生理盐水对照。对乙醇抗惊厥作用（实验1和2）的耐受性在每次惊厥刺激前接受乙醇的大鼠中最大；而在接受乙醇的两组大鼠中均产生了对乙醇降温作用（实验1和2）和共济失调作用（实验2）的耐受性。这些结果是基于药物耐受性的药物效应理论预测的：即功能性药物耐受性是对药物对并发神经活动模式的破坏作用的一种适应，而非对药物暴露本身的适应。
