Biver F, Goldman S, Luxen A, Delvenne V, De Maertelaer V, De La Fuente J, Mendlewicz J, Lotstra F
Psychiatry Department, Erasme Hospital, Brussels, Belgium.
Psychiatry Res. 1995 Sep 29;61(3):161-71. doi: 10.1016/0925-4927(95)02672-k.
Positron emission tomography with [18F]-fluoro-2-deoxy-D-glucose as tracer was used to investigate frontal glucose metabolism in 15 unmedicated schizophrenic patients and 15 healthy subjects under resting conditions. Although no difference in absolute frontal cerebral metabolic rates of glucose (CMRglu) were found between schizophrenic patients and control subjects, relative measures significantly differentiated the two groups. Whole frontal metabolism and frontocaudate ratio were significantly decreased in both hemispheres in the patients. The results confirm the existence of hypofrontality in unmedicated schizophrenia and indicate disturbances in metabolic relationships between the frontal cortex and the striatum in this disorder.
以[18F] - 氟 - 2 - 脱氧 - D - 葡萄糖作为示踪剂的正电子发射断层扫描被用于研究15名未服药的精神分裂症患者和15名健康受试者在静息状态下的额叶葡萄糖代谢。尽管在精神分裂症患者和对照受试者之间未发现绝对额叶脑葡萄糖代谢率（CMRglu）有差异，但相对测量值显著区分了两组。患者双侧半球的整个额叶代谢和额尾状核比率均显著降低。结果证实了未服药的精神分裂症患者存在额叶功能低下，并表明该疾病中额叶皮质与纹状体之间的代谢关系存在紊乱。
