精神病中预测误差信号的破坏：妄想联想解释的证据。
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions.
作者信息
Corlett P R, Murray G K, Honey G D, Aitken M R F, Shanks D R, Robbins T W, Bullmore E T, Dickinson A, Fletcher P C
机构信息
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
出版信息
Brain. 2007 Sep;130(Pt 9):2387-400. doi: 10.1093/brain/awm173. Epub 2007 Aug 9.
Abstract
Delusions are maladaptive beliefs about the world. Based upon experimental evidence that prediction error-a mismatch between expectancy and outcome--drives belief formation, this study examined the possibility that delusions form because of disrupted prediction--error processing. We used fMRI to determine prediction-error-related brain responses in 12 healthy subjects and 12 individuals (7 males) with delusional beliefs. Frontal cortex responses in the patient group were suggestive of disrupted prediction-error processing. Furthermore, across subjects, the extent of disruption was significantly related to an individual's propensity to delusion formation. Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs.
摘要
妄想是关于世界的适应不良信念。基于预测误差（预期与结果之间的不匹配）驱动信念形成的实验证据，本研究探讨了妄想形成是由于预测误差处理中断的可能性。我们使用功能磁共振成像（fMRI）来确定12名健康受试者和12名有妄想信念的个体（7名男性）中与预测误差相关的大脑反应。患者组的额叶皮质反应提示预测误差处理中断。此外，在所有受试者中，中断程度与个体的妄想形成倾向显著相关。我们的结果支持一种妄想形成的神经生物学理论，该理论认为异常的预测误差信号、注意力分配中断和联想学习与妄想信念的形成有关。
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