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The benzodiazepine receptor antagonists flumazenil and CGS8216 block the enhancement of fear conditioning and interference with escape behavior produced by inescapable shock.

作者信息

Maier S F, Grahn R E, Maswood S, Watkins L R

机构信息

Department of Psychology, University of Colorado, Boulder 80309-0345, USA.

出版信息

Psychopharmacology (Berl). 1995 Sep;121(2):250-8. doi: 10.1007/BF02245636.

DOI:10.1007/BF02245636
PMID:8545531
Abstract

Prior work has suggested that the mediation of the behavioral effects of inescapable shock (IS) might involve release of an endogenous beta-carboline-like ligand at the dorsal raphe nucleus (DRN) that binds to the benzodiazepine (BZ) recognition site on the GABAA complex, thereby disinhibiting the DRN. This was tested by microinjection of the BZ receptor antagonists flumazenil and CGS8216 in the region of the DRN, either before IS or before later behavioral testing. Both compounds blocked subsequent enhancement of fear conditioning and interference with shuttlebox escape when administered before IS, but had no effect when given before testing. In addition, flumazenil did not alter the behavior of escapably shocked subjects.

摘要

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本文引用的文献

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The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.杏仁核和中缝背核在介导不可逃避电击行为后果中的作用。
Behav Neurosci. 1993 Apr;107(2):377-88. doi: 10.1037//0735-7044.107.2.377.
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Stressor controllability, social interaction, and benzodiazepine systems.应激源可控性、社会互动与苯二氮䓬系统。
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Chlordiazepoxide microinjected into the region of the dorsal raphe nucleus eliminates the interference with escape responding produced by inescapable shock whether administered before inescapable shock or escape testing.
背侧纹状体中的 5-羟色胺 2C 受体介导应激引起的负强化工具性逃避行为的干扰。
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Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects.β-咔啉FG-7142的药理学研究，它是GABAA受体苯二氮䓬变构位点的部分反向激动剂：神经化学、神经生理学及行为学效应
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将氯氮卓微量注射到中缝背核区域，无论在不可逃避电击之前还是逃避测试之前给药，均可消除不可逃避电击对逃避反应产生的干扰。
Behav Neurosci. 1994 Feb;108(1):121-30. doi: 10.1037//0735-7044.108.1.121.
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The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists.压力控制的保护作用可能是通过大脑中苯二氮䓬受体激动剂水平的升高来介导的。
Brain Res. 1994 Oct 24;661(1-2):127-36. doi: 10.1016/0006-8993(94)91189-4.
5
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6
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Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.地西泮以及苯二氮䓬拮抗剂Ro 15 - 1788和CGS 8216对3 - 甲氧羰基-β-咔啉诱发癫痫发作的阻断作用
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Role of norepinephrine in regulating the activity of serotonin-containing dorsal raphe neurons.
Life Sci. 1984 Jul 30;35(5):511-5. doi: 10.1016/0024-3205(84)90244-3.
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Librium prevents the analgesia and shuttlebox escape deficit typically observed following inescapable shock.
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