Ellison G, Liminga U, Keys A
Department of Psychology, UCLA 90024, USA.
Psychopharmacology (Berl). 1995 Sep;121(2):259-66. doi: 10.1007/BF02245637.
Rats were pretreated for 11 months with vehicle or with chronic haloperidol (HAL), administered either continuously (in the drinking water) or intermittently (via weekly injections). During this time the animals were habituated to an enclosed tube and periodically monitored by a computerized video device which measured their oral movements. The rats were then withdrawn from chronic HAL and bilateral cannulae were implanted in the ventrolateral striatum (VLS) and substantia nigra (SN). One week later oral movements were observed in an open cage and then measured by the computerized video device following bilateral infusions into VLS of the muscarinic agonist pilocarpine or the dopamine D1 agonist SKF38393, or following infusions of the GABA antagonist bicuculline into SN. Agonist infusions into VLS had different effects depending upon the prior regimen of chronic HAL. Infusions of pilocarpine into VLS led to an exaggeration of the distinctive oral movement form which follows continuous HAL but an attenuation of the different oral syndrome in the intermittent chronic HAL animals. Infusions of SKF38393 into VLS had similar, but considerably smaller effects. Infusions of bicuculline into SN did not induce either effect. These results indicate differences exist in either striatum or its output circuitry in the neurochemical mechanisms which mediate the different oral movement forms induced by different chronic neuroleptic regimens.
将大鼠用溶剂或慢性给予氟哌啶醇（HAL）预处理11个月，氟哌啶醇连续（通过饮用水）或间歇（通过每周注射）给药。在此期间，使动物适应封闭的管子，并通过测量其口腔运动的计算机化视频设备定期进行监测。然后将大鼠从慢性HAL处理中撤药，并在腹外侧纹状体（VLS）和黑质（SN）中植入双侧套管。一周后，在开放笼中观察口腔运动，并在向VLS双侧注入毒蕈碱激动剂毛果芸香碱或多巴胺D1激动剂SKF38393后，或在向SN注入GABA拮抗剂荷包牡丹碱后，通过计算机化视频设备进行测量。根据慢性HAL的先前给药方案，向VLS注入激动剂会产生不同的效果。向VLS注入毛果芸香碱会导致连续给予HAL后出现的独特口腔运动形式加剧，但在间歇性慢性HAL动物中不同的口腔综合征会减轻。向VLS注入SKF38393有类似但程度小得多的效果。向SN注入荷包牡丹碱不会诱导任何一种效果。这些结果表明，在介导不同慢性抗精神病药物方案诱导的不同口腔运动形式的神经化学机制中，纹状体或其输出回路存在差异。
