Sirigu F, Dessì A, Usai P, Capeccioni S, Masia A M
Istituto di Medicina Interna, Università di Cagliari.
Riv Eur Sci Med Farmacol. 1995 Mar-Jun;17(2-3):85-9.
To investigate the relationship between lymphocytic gastritis and H. pylori infection, antral biopsy specimens from 162 patients with histological evidence of H. pylori infection, and from 177 subjects without colonization were retrospectively examined. Among patients with antral colonization, lymphocytic gastritis was identified in 8 cases (4.9%). Lymphocytic gastritis was not detected in specimens without H. pylori infection. Quantitation of the epithelial lymphocytic infiltration was carried out in all specimens and showed that cases with lymphocytic gastritis had a mean of 35.3 lymphocytes per 100 epithelial cells, compared with a mean of 2.6 and 2.4 respectively in chronic gastritis and normal mucosa. Among the 331 patients without lymphocytic gastritis, specimens colonized by H. pylori had a mean of epithelial lymphocyte counts significantly higher than those observed in both chronic gastritis and normal mucosa. These findings show a positive correlation between antral colonization by H. pylori and occurrence of lymphocytic gastritis, and suggest that the bacteria may have an important role in the induction of such particular form of antral inflammation.
为研究淋巴细胞性胃炎与幽门螺杆菌感染之间的关系，我们对162例有幽门螺杆菌感染组织学证据的患者及177例无幽门螺杆菌定植的受试者的胃窦活检标本进行了回顾性检查。在胃窦定植的患者中，8例（4.9%）被诊断为淋巴细胞性胃炎。在无幽门螺杆菌感染的标本中未检测到淋巴细胞性胃炎。对所有标本进行上皮淋巴细胞浸润定量分析，结果显示，淋巴细胞性胃炎患者每100个上皮细胞中淋巴细胞的平均数为35.3个，而慢性胃炎和正常黏膜中该平均数分别为2.6个和2.4个。在331例无淋巴细胞性胃炎的患者中，幽门螺杆菌定植的标本上皮淋巴细胞计数平均数显著高于慢性胃炎和正常黏膜中的计数。这些发现表明幽门螺杆菌胃窦定植与淋巴细胞性胃炎的发生呈正相关，并提示该细菌可能在诱发这种特殊形式的胃窦炎症中起重要作用。
