Brønnum-Hansen H, Koch-Henriksen N J, Hyllested K
Dansk Institut for Klinisk Epidemiologi, København.
Ugeskr Laeger. 1995 Dec 18;157(51):7131-5.
We estimated survival probability and excess death rates for patients with multiple sclerosis (MS) on the basis of data from the Danish Multiple Sclerosis Registry, which includes virtually all patients diagnosed with MS in Denmark since 1948. We reviewed and reclassified all case records according to standardized diagnostic criteria. By linkage to the Danish Central Population Registry and the National Registry of Causes of Death complete follow-up of all MS patients was achieved, with the exception of 25 patients who had emigrated. A total of 2300 of the 6727 MS patients included in the study had died before the onset of the disease was 28 years in men (compared with 40 years in the matched general male population) and 33 years in women (versus 46 years). The excess death rate between onset and follow-up (observed deaths per 1000 person-year minus the expected number of deaths in a matched general population) was 14.3 in men, which was significantly higher than in women (12.0). Excess mortality increased with age at onset of MS in people of each sex. The 10-year excess death rate has decreased significantly in recent decades. Excess mortality was highest in cases with cerebellar symptoms at onset.
我们基于丹麦多发性硬化症登记处的数据，估算了多发性硬化症（MS）患者的生存概率和超额死亡率。该登记处涵盖了自1948年以来丹麦几乎所有被诊断为MS的患者。我们根据标准化诊断标准对所有病例记录进行了审查和重新分类。通过与丹麦中央人口登记处和国家死亡原因登记处的关联，除25名移民患者外，实现了对所有MS患者的完整随访。在纳入研究的6727名MS患者中，共有2300人在疾病发病前死亡，男性为28岁（匹配的普通男性人群为40岁），女性为33岁（匹配的普通女性人群为46岁）。发病至随访期间的超额死亡率（每1000人年观察到的死亡人数减去匹配的普通人群中的预期死亡人数）男性为14.3，显著高于女性（12.0）。各性别中，MS发病时的超额死亡率均随年龄增加。近几十年来，10年超额死亡率显著下降。发病时有小脑症状的病例超额死亡率最高。
