Brønnum-Hansen H, Koch-Henriksen N, Hyllested K
Danish Institute for Clinical Epidemiology, Copenhagen.
Neurology. 1994 Oct;44(10):1901-7. doi: 10.1212/wnl.44.10.1901.
We estimated survival probability and excess death rates for patients with MS on the basis of data from the Danish Multiple Sclerosis Registry, which includes virtually all patients diagnosed with MS in Denmark (population, five million) since 1948. We reviewed and reclassified all case records according to standardized diagnostic criteria. By linkage to the Danish Central Population Registry, we lost to follow-up only 25 patients who had emigrated. The median survival time from onset of the disease was 28 years in men (compared with 40 years in the matched general male population) and 33 years in women (versus 46 years). The median survival time from diagnosis was 22 years in men (versus 37 years) and 28 years in women (versus 42 years). The excess death rate between onset and follow-up (observed deaths per 1,000 person-years minus the expected number of deaths in a matched general population) was 14.3 in men, which was significantly higher than in women (12.0). Excess mortality increased with age at onset of MS in people of each sex. The 10-year excess death rate has decreased significantly in recent decades. Excess mortality was highest in cases with cerebellar symptoms at onset.
我们根据丹麦多发性硬化症登记处的数据估算了多发性硬化症患者的生存概率和超额死亡率，该登记处收录了自1948年以来丹麦（人口500万）几乎所有被诊断为多发性硬化症的患者。我们根据标准化诊断标准对所有病例记录进行了复查和重新分类。通过与丹麦中央人口登记处的数据关联，我们仅失访了25名移民患者。疾病发病后的中位生存时间，男性为28年（与之匹配的普通男性人群为40年），女性为33年（与之匹配的普通女性人群为46年）。诊断后的中位生存时间，男性为22年（与之匹配的普通男性人群为37年），女性为28年（与之匹配的普通女性人群为42年）。发病至随访期间的超额死亡率（每1000人年观察到的死亡人数减去与之匹配的普通人群中预期的死亡人数），男性为14.3，显著高于女性（12.0）。各性别中，多发性硬化症发病时的超额死亡率均随年龄增长而升高。近几十年来，10年超额死亡率显著下降。发病时伴有小脑症状的病例超额死亡率最高。
