Szylman P, Benzakin A, Szjnader Y, Taitelman U
Renal Unit, Poriah Government Hospital, Tiberias, Israel.
Am J Nephrol. 1995;15(6):514-20. doi: 10.1159/000168898.
An outbreak of organic mercurial intoxication in a peasant family from the Jordan West Bank is reported. Extrapyramidal symptoms, muscular wasting, oral ulcerations, and renal tubular dysfunction were the main manifestations. Hpyokalemia (1.9-2.7 mEq/l) due to urinary potassium wasting was present in all 4 patients. Type II RTA was observed in 2 cases. Urinary ammonium excretion was increased over the range predicted by the given urinary pH in all the patients. Intrinsic tubular damage, nonreabsorbable anions of catabolic origin, increased prostaglandin synthesis inducing renin-angiotensin axis activation, and, consequently, inappropriate relatively high levels of aldosterone, are advanced as an explanation for potassium wasting.
据报道，约旦河西岸一个农民家庭爆发了有机汞中毒事件。锥体外系症状、肌肉萎缩、口腔溃疡和肾小管功能障碍是主要表现。所有4例患者均因尿钾流失出现低钾血症（1.9 - 2.7 mEq/l）。2例患者观察到II型肾小管性酸中毒。所有患者尿铵排泄量均高于根据给定尿pH值预测的范围。肾小管的内在损伤、分解代谢产生的不可重吸收阴离子、前列腺素合成增加导致肾素 - 血管紧张素轴激活，进而导致醛固酮水平相对异常升高，被认为是钾流失的原因。
