Taivainen T, Meretoja O A
Department of Anaesthesia, Children's Hospital, University of Helsinki, Finland.
Anaesthesia. 1995 Dec;50(12):1046-9. doi: 10.1111/j.1365-2044.1995.tb05948.x.
Forty-five children aged 5-12 years were randomly allocated to receive 1.0 MAC of sevoflurane or halothane, or balanced anaesthesia with propofol and alfentanil. The ulnar nerve was stimulated every 20 s supramaximally with a train-of-four pattern and adductor pollicis electromyography was recorded. A cumulative log-probit dose-response curve of vecuronium was established. Thereafter, spontaneous recovery of neuromuscular function was monitored until complete. Effective doses of vecuronium were lowest in the sevoflurane group and greatest during balanced anaesthesia; for 50% neuromuscular blockade these were 13.3% micrograms.kg-1, 21.8 micrograms.kg-1 and 36.6 micrograms.kg-1 during sevoflurane, halothane and balanced anaesthesia, respectively, p < 0.05. Recovery of neuromuscular function was slower during sevoflurane than during halothane or balanced anaesthesia. Sevoflurane potentiated vecuronium more than halothane; when compared to balanced anaesthesia the dose requirements of vecuronium were reduced by approximately 60% and 40%, respectively.
45名5至12岁的儿童被随机分配接受1.0 MAC的七氟烷或氟烷，或丙泊酚和阿芬太尼的平衡麻醉。每隔20秒用四个成串刺激模式对尺神经进行超强刺激，并记录拇收肌肌电图。建立维库溴铵的累积对数概率剂量反应曲线。此后，监测神经肌肉功能的自发恢复直至完全恢复。维库溴铵的有效剂量在七氟烷组中最低，在平衡麻醉期间最高；对于50%的神经肌肉阻滞，七氟烷、氟烷和平衡麻醉期间的剂量分别为13.3微克·千克-1、21.8微克·千克-1和36.6微克·千克-1，p<0.05。七氟烷麻醉期间神经肌肉功能的恢复比氟烷或平衡麻醉期间慢。七氟烷比氟烷更能增强维库溴铵的作用；与平衡麻醉相比，维库溴铵的剂量需求分别降低了约60%和40%。
