Visonà A, Pesavento R, Lusiani L, Bonanome A, Cernetti C, Rossi M, Maiolino P, Pagnan A
Department of Internal Medicine, University of Padova, Italy.
Angiology. 1996 Jan;47(1):61-6. doi: 10.1177/000331979604700109.
The authors investigated the relation between coronary atherosclerosis, angiographically detected, and intimal-medial (I-M) thickening of the common carotid artery (CCA), as measured by high-resolution B-mode ultrasound system. They studied 31 patients with coronary artery disease (CAD) and 23 healthy control subjects. I-M thickening of CCAs and atheromatous plaques at the carotid bifurcation were evaluated. A score system was defined (range 0-20) based on the absence or presence of atherosclerotic lesions at common and internal carotid arteries. A coronary angiography score was defined based on the presence of of atherosclerotic lesions at nine coronary arterial segments (range 0-36). The thickness of CCAs (M +/- SD) in CAD patients was significantly higher (1.45 +/- 0.95 mm) than in controls (0.87 +/- 0.10 mm, P < 0.005), and an I-M thickening of 1.1 mm or more was specific and positively predictive of CAD. A significant positive correlation between coronary and carotid score was observed (P < 0.028, r = 0.373). The study suggests that I-M thickening could be helpful for the identification of patients at risk for CAD.
作者通过高分辨率B型超声系统，研究了血管造影检测到的冠状动脉粥样硬化与颈总动脉（CCA）内膜中层（I-M）增厚之间的关系。他们研究了31例冠心病（CAD）患者和23名健康对照者。评估了CCA的I-M增厚情况以及颈动脉分叉处的动脉粥样斑块。根据颈总动脉和颈内动脉有无动脉粥样硬化病变定义了一个评分系统（范围0-20）。根据九个冠状动脉节段有无动脉粥样硬化病变定义了冠状动脉造影评分（范围0-36）。CAD患者的CCA厚度（M±SD）显著高于对照组（1.45±0.95mm比0.87±0.10mm，P<0.005），I-M增厚1.1mm或更多对CAD具有特异性且为阳性预测指标。观察到冠状动脉评分与颈动脉评分之间存在显著正相关（P<0.028，r=0.373）。该研究表明，I-M增厚可能有助于识别CAD高危患者。
