Barnes L, Ferlito A, Altavilla G, MacMillan C, Rinaldo A, Doglioni C
Division of Head and Neck Pathology, Presbyterian-University Hospital, Pittsburgh, Pennsylvania, USA.
Ann Otol Rhinol Laryngol. 1996 Jan;105(1):75-82. doi: 10.1177/000348949610500115.
Basaloid squamous cell carcinoma is a recently recognized variant of squamous cell carcinoma. The lesion is histologically distinctive and manifests a predilection for the supraglottis, pyriform sinus, and tongue base. The immunohistochemical profile is discussed. The differential diagnoses include adenoid cystic carcinoma, small cell neuroendocrine carcinoma, basal cell adenocarcinoma, adenosquamous carcinoma, squamous cell carcinoma, spindle cell squamous carcinoma, mucoepidermoid carcinoma, and adenoid squamous cell carcinoma. Basaloid squamous cell carcinoma is a biologically high-grade tumor with a propensity for nodal as well as systemic metastases. It is a morphologic and phenotypic entity with a separate prognostic significance.
基底样鳞状细胞癌是一种最近才被认识的鳞状细胞癌变体。该病变在组织学上具有独特性，好发于声门上区、梨状窝和舌根。文中讨论了其免疫组化特征。鉴别诊断包括腺样囊性癌、小细胞神经内分泌癌、基底细胞腺癌、腺鳞癌、鳞状细胞癌、梭形细胞鳞状癌、黏液表皮样癌和腺样鳞状细胞癌。基底样鳞状细胞癌是一种生物学上的高级别肿瘤，有发生淋巴结转移和全身转移的倾向。它是一种具有独立预后意义的形态学和表型实体。
