Somekawa Y, Asano K, Taira A, Imai R
Dept. of Otolaryngology, Tonan Hospital.
Gan To Kagaku Ryoho. 1996 Jan;23(1):75-9.
We determined the 5-FU concentrations in the tumor tissue, normal tissue surrounding the tumor, metastatic lymph nodes, normal lymph nodes, and serum after oral UFT administration to 26 patients with primary squamous cell carcinoma in the head and neck. The 5-FU concentration was mean 0.20 +/- 0.13 micrograms/g in the tumor tissue and mean 0.14 +/- 0.08 micrograms/g in the metastatic lymph nodes. The 5-FU concentrations in the tumor tissue and metastatic lymph nodes were significantly higher than in the corresponding normal tissue surrounding the tumor and normal lymph nodes. In addition, the 5-FU concentration was significantly higher in the tumor tissue than in the metastatic lymph nodes. No significant differences were observed in the 5-FU concentration according to the sites of the primary tumor. However, the difference in the 5-FU concentration between the tumor and normal tissues was smaller in tongue cancer than in pharyngeal cancer.
我们测定了26例原发性头颈部鳞状细胞癌患者口服优福定（UFT）后肿瘤组织、肿瘤周围正常组织、转移淋巴结、正常淋巴结及血清中的5-氟尿嘧啶（5-FU）浓度。肿瘤组织中5-FU浓度平均为0.20±0.13微克/克，转移淋巴结中平均为0.14±0.08微克/克。肿瘤组织和转移淋巴结中的5-FU浓度显著高于相应的肿瘤周围正常组织和正常淋巴结。此外，肿瘤组织中的5-FU浓度显著高于转移淋巴结。未观察到5-FU浓度根据原发肿瘤部位的显著差异。然而，舌癌中肿瘤组织与正常组织之间5-FU浓度的差异小于咽癌。
