Graham S J, Bronskill M J, Byng J W, Yaffe M J, Boyd N F
Department of Medical Biophysics, University of Toronto, Sunnybrook Health Science Centre, Ontario, Canada.
Br J Cancer. 1996 Jan;73(2):162-8. doi: 10.1038/bjc.1996.30.
Previous investigators have shown that there is a strong association between the fraction of fibroglandular tissue within the breast as determined by X-ray mammography (per cent density) and breast cancer risk. In this study, the quantitative correlation between per cent density and two objective magnetic resonance (MR) parameters of breast tissue, relative water content and mean T2 relaxation time, as investigated for 42 asymptomatic subjects. Using newly developed, rapid techniques MR measurements were performed on a volume-of-interest incorporating equal, representative portions of both breasts. X-ray mammograms of each subject were digitised and analysed semiautomatically to determine per cent density. Relative water content showed a strong positive correlation with per cent density (Pearson correlation coefficient rp = 0.79, P < 0.0001) and mean T2 value showed a strong negative correlation with per cent density (rp = -0.61, P < 0.0001). The MR and X-ray parameters were also associated with sociodemographic and anthropometric risk factors for breast cancer (P < 0.05). The potential use of MR parameters to assess risk of breast cancer and to provide a frequent, non-hazardous monitor of breast parenchyma is discussed.
先前的研究人员已经表明，通过乳腺X线摄影术测定的乳腺内纤维腺组织的比例（密度百分比）与乳腺癌风险之间存在密切关联。在本研究中，对42名无症状受试者的乳腺组织的密度百分比与两个客观的磁共振（MR）参数——相对含水量和平均T2弛豫时间——之间的定量相关性进行了研究。使用新开发的快速技术，对包含双侧乳房相等、代表性部分的感兴趣体积进行了MR测量。对每个受试者的乳腺X线照片进行数字化处理并半自动分析，以确定密度百分比。相对含水量与密度百分比呈强正相关（Pearson相关系数rp = 0.79，P < 0.0001），平均T2值与密度百分比呈强负相关（rp = -0.61，P < 0.0001）。MR和X线参数也与乳腺癌的社会人口统计学和人体测量学风险因素相关（P < 0.05）。讨论了使用MR参数评估乳腺癌风险以及对乳腺实质进行频繁、无危害监测的潜在用途。
