Genetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA, Australia.
University Health Network, Toronto, ON, Canada.
Br J Cancer. 2023 May;128(9):1701-1709. doi: 10.1038/s41416-023-02201-5. Epub 2023 Feb 24.
Breast density is a strong and potentially modifiable breast cancer risk factor. Almost everything we know about breast density has been derived from mammography, and therefore, very little is known about breast density in younger women aged <40. This study examines the acceptability and performance of two alternative breast density measures, Optical Breast Spectroscopy (OBS) and Dual X-ray Absorptiometry (DXA), in women aged 18-40.
Breast tissue composition (percent water, collagen, and lipid content) was measured in 539 women aged 18-40 using OBS. For a subset of 169 women, breast density was also measured via DXA (percent fibroglandular dense volume (%FGV), absolute dense volume (FGV), and non-dense volume (NFGV)). Acceptability of the measurement procedures was assessed using an adapted validated questionnaire. Performance was assessed by examining the correlation and agreement between the measures and their associations with known determinants of mammographic breast density.
Over 93% of participants deemed OBS and DXA to be acceptable. The correlation between OBS-%water + collagen and %FGV was 0.48. Age and BMI were inversely associated with OBS-%water + collagen and %FGV and positively associated with OBS-%lipid and NFGV.
OBS and DXA provide acceptable and viable alternative methods to measure breast density in younger women aged 18-40 years.
乳房密度是一种较强的、潜在可改变的乳腺癌风险因素。我们目前几乎对所有关于乳房密度的了解都源自乳房 X 光摄影术，因此，对于年龄<40 岁的年轻女性，我们对乳房密度的了解非常有限。本研究旨在评估光学乳腺光谱术（OBS）和双能 X 线吸收法（DXA）两种替代乳房密度测量方法在 18-40 岁女性中的可接受性和性能。
使用 OBS 测量了 539 名 18-40 岁女性的乳房组织成分（水、胶原蛋白和脂肪含量的百分比）。对于 169 名女性的亚组，还通过 DXA 测量了乳房密度（纤维腺体致密体积百分比 (%FGV)、致密体积绝对值 (FGV) 和非致密体积 (NFGV)）。采用经过验证的改良问卷评估测量程序的可接受性。通过检查各指标之间的相关性和一致性，以及它们与已知的乳房 X 光摄影术乳房密度决定因素的相关性，来评估性能。
超过 93%的参与者认为 OBS 和 DXA 是可接受的。OBS-%water+collagen 与 %FGV 的相关性为 0.48。年龄和 BMI 与 OBS-%water+collagen 和 %FGV 呈负相关，与 OBS-%lipid 和 NFGV 呈正相关。
OBS 和 DXA 为 18-40 岁年轻女性提供了可接受且可行的替代乳房密度测量方法。
