Keller E, Gieseke J, Kossack D, Sommer T, Lutterbey G, Kuhl C, Schild H H
Radiologische Klinik, Universität Bonn.
Rofo. 1995 Dec;163(6):497-504. doi: 10.1055/s-2007-1016036.
Aim of the study was to evaluate FLAIR combined with Turbo-Spin-Echo (Turbo-FLAIR) at 0.5 tesla in comparison to conventional T1- and T2-weighted spin-echo images (SE) in MRI of the brain.
A Turbo-FLAIR sequence was optimised for 0.5 Tesla (Philips Gyroscan T5-II) that provided seventeen 5 mm sections in 4:21 minutes (TR = 6075 ms, T1 = 1600 ms, TE = 120 ms and a turbofactor = 17). Images were compared with T1- (TR = 500 ms, TE = 15 ms) proton density and T2-weighted spin-echo (TR = 2500 ms, TE = 20/90 ms) studies in 10 healthy volunteers and 30 patients with various brain pathologies.
Turbo-FLAIR could effectively eliminate the CSF signal in all studies except ventricular areas with CSF inflow. Contrast-to-noise ratios (C/N) for the contrast between lesions and CSF was superior in Turbo-FLAIR. C/N between lesions and grey matter was significantly higher in Turbo-FLAIR than in proton density (PD)-weighted SE. C/N between lesions and white matter was equal to PD-weighted SE but significantly smaller than on T2-weighted SE. Visual analysis showed greater lesions conspicuity with Turbo-FLAIR and a higher frequency of detection of cortical and subcortical lesions.
Turbo-FLAIR is a reliable and practical technique on 0.5 Tesla, that is more sensitive than SE sequences especially for the detection of cortical, subcortical lesions and lesions surrounded by CSF.
本研究旨在评估0.5特斯拉场强下的液体衰减反转恢复序列（FLAIR）联合快速自旋回波序列（Turbo-FLAIR），并与脑部磁共振成像（MRI）中的传统T1加权和T2加权自旋回波图像（SE）进行比较。
针对0.5特斯拉（飞利浦Gyroscan T5-II）优化了Turbo-FLAIR序列，该序列在4分21秒内提供17层5毫米厚的图像（重复时间[TR]=6075毫秒，T1=1600毫秒，回波时间[TE]=120毫秒，涡轮因子=17）。将这些图像与10名健康志愿者和30名患有各种脑部疾病的患者的T1加权（TR=500毫秒，TE=15毫秒）质子密度图像以及T2加权自旋回波（TR=2500毫秒，TE=20/90毫秒）图像进行比较。
除脑脊液流入的脑室区域外，Turbo-FLAIR在所有研究中均能有效消除脑脊液信号。Turbo-FLAIR中病变与脑脊液之间的对比度噪声比（C/N）更高。Turbo-FLAIR中病变与灰质之间的C/N显著高于质子密度（PD）加权SE。病变与白质之间的C/N与PD加权SE相等，但显著小于T2加权SE。视觉分析显示，Turbo-FLAIR对病变的显示更好，皮质和皮质下病变的检出频率更高。
Turbo-FLAIR在0.5特斯拉场强下是一种可靠且实用的技术，比SE序列更敏感，尤其对于检测皮质、皮质下病变以及被脑脊液包围的病变。
