Ogawa Y, Inada K, Tsutsumi Y
Pathol Int. 1995 Sep;45(9):698-701. doi: 10.1111/j.1440-1827.1995.tb03525.x.
A peculiar form of reactive, non-granulomatous proliferation of CD68+ histiocytes was demonstrated, for the first time, in the submucosal layer just beneath the IIa-type early gastric adenocarcinoma that focally invaded submucosal lymphatics. The histiocytic cells possessed plump eosinophilic and often foamy cytoplasm and eccentric small nuclei with apparent nucleoli. They contained periodic acid-Schiff-reactive granules, and were further immunoreactive for lysozyme and alpha 1-antitrypsin. The infiltration was ill-defined, and partly involved the tunica muscularis mucosae and the proper muscle layer. Markers of epithelial cells, Langerhans' histiocytes, smooth muscle cells and myofibroblasts were all negative.
首次在局部侵犯黏膜下淋巴管的IIa型早期胃腺癌下方的黏膜下层发现了一种特殊形式的CD68 +组织细胞反应性、非肉芽肿性增殖。组织细胞具有丰满的嗜酸性且常呈泡沫状的细胞质以及带有明显核仁的偏心小核。它们含有对高碘酸-希夫反应呈阳性的颗粒，并且对溶菌酶和α1-抗胰蛋白酶进一步呈免疫反应性。浸润边界不清，部分累及黏膜肌层和固有肌层。上皮细胞、朗格汉斯组织细胞、平滑肌细胞和成肌纤维细胞的标志物均为阴性。
