NBQX，一种在视网膜神经节细胞中进行研究的改良型非NMDA拮抗剂。
NBQX, an improved non-NMDA antagonist studied in retinal ganglion cells.
作者信息
Yu W, Miller R F
机构信息
Department of Physiology, University of Minnesota, Minneapolis 55455, USA.
出版信息
Brain Res. 1995 Sep 18;692(1-2):190-4. doi: 10.1016/0006-8993(95)00665-d.
The quinoxaline derivative, 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo (F) quinoxaline (NBQX), significantly reduced the currents evoked by exogenous application of quisqualate (QQ), kainate (KA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) when applied to ganglion cells, using whole-cell recording in a slice preparation of the tiger salamander retina. A comparison between NBQX and CNQX indicates that NBQX is more effective in blocking AMPA receptors. Also, at up to 10 microM, NBQX has no effect on NMDA-induced currents. Thus at this concentration, NBQX shows no affinity for the glycine binding site of NMDA receptors. For this reason, NBQX is preferred over CNQX for a more effective and selective antagonism toward non-NMDA receptors.
喹喔啉衍生物2,3 - 二羟基 - 6 - 硝基 - 7 - 氨磺酰基苯并(F)喹喔啉（NBQX），在虎蝾螈视网膜切片制备中采用全细胞记录法应用于神经节细胞时，能显著降低外源性施加喹氨酸（QQ）、海人酸（KA）和α - 氨基 - 3 - 羟基 - 5 - 甲基异恶唑 - 4 - 丙酸（AMPA）所诱发的电流。NBQX与CNQX的比较表明，NBQX在阻断AMPA受体方面更有效。此外，在高达10微摩尔的浓度下，NBQX对NMDA诱导的电流没有影响。因此，在此浓度下，NBQX对NMDA受体的甘氨酸结合位点没有亲和力。基于这个原因，与CNQX相比，NBQX更适合用于对非NMDA受体进行更有效和选择性的拮抗。
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