大鼠雄性交配行为期间内侧视前区多巴胺的释放

Dopamine release in the medial preoptic area during male copulatory behavior in rats.

作者信息

Sato Y, Wada H, Horita H, Suzuki N, Shibuya A, Adachi H, Kato R, Tsukamoto T, Kumamoto Y

机构信息

Department of Urology, Sapporo Medical University School of Medicine, Japan.

出版信息

Brain Res. 1995 Sep 18;692(1-2):66-70. doi: 10.1016/0006-8993(95)00656-b.

DOI:10.1016/0006-8993(95)00656-b

PMID:8548321

Abstract

In vivo microdialysis was employed to measure the extracellular concentrations of dopamine (DA) in the medial preoptic area (MPOA) of rats during male sexual activity to look for a correlation with sexual activity. During copulation, the concentration of DA in the MPOA was significantly increased. A significant difference was detected in changes of DA between copulators and non-copulators. These findings were consistent with the assertion that DA neuron activity in the MPOA facilities male copulatory behavior.

摘要

采用体内微透析技术测量雄性大鼠性行为期间内侧视前区（MPOA）细胞外多巴胺（DA）的浓度，以寻找其与性行为的相关性。在交配过程中，MPOA中DA的浓度显著升高。交配者与未交配者之间DA的变化存在显著差异。这些发现与MPOA中DA神经元活动促进雄性交配行为的观点一致。