CGS 26529: the biological profile of a novel, orally active 5-lipoxygenase inhibitor with an extended duration of action.

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作者信息

Kimble E, Kowalski T, Peters P, Lee W, Koehler J, Raychaudhuri A, Chertock H, Blancuzzi V, van Duzer J

机构信息

Research Department, Ciba-Geigy Corp., Summit, NJ 07901, USA.

出版信息

Inflamm Res. 1995 Aug;44 Suppl 2:S147-8. doi: 10.1007/BF01778305.

DOI:10.1007/BF01778305

PMID:8548371

Abstract

摘要

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本文引用的文献

Influence of indomethacin and other anti-inflammatory drugs on mobilization and production of neutrophils: studies with carrageenan-induced inflammation in rats.

J Pharmacol Exp Ther. 1980 Jul;214(1):74-9.

Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.白三烯：速发型超敏反应和炎症的介质。

Science. 1983 May 6;220(4597):568-75. doi: 10.1126/science.6301011.

Development of a system for evaluating 5-lipoxygenase inhibitors using human whole blood.利用人全血开发一种评估5-脂氧合酶抑制剂的系统。

Prostaglandins Leukot Med. 1987 Jun;28(1):73-93. doi: 10.1016/0262-1746(87)90049-7.

Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models.使用体外和体内模型将CGS 8515表征为选择性5-脂氧合酶抑制剂。

Biochim Biophys Acta. 1988 Apr 15;959(3):332-42. doi: 10.1016/0005-2760(88)90207-x.

Involvement of leukotriene C4 in PAF-induced death in mice.白三烯C4参与血小板活化因子诱导的小鼠死亡。

Prostaglandins Leukot Essent Fatty Acids. 1990 Apr;39(4):291-4. doi: 10.1016/0952-3278(90)90008-9.

5-lipoxygenase inhibitory activity of zileuton.齐留通的5-脂氧合酶抑制活性。

J Pharmacol Exp Ther. 1991 Mar;256(3):929-37.

CGS 22745: a selective orally active inhibitor of 5-lipoxygenase.CGS 22745：一种5-脂氧合酶的选择性口服活性抑制剂。

Agents Actions. 1991 Sep;34(1-2):125-8. doi: 10.1007/BF01993256.

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