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Leflunomide, a reversible inhibitor of pyrimidine biosynthesis?

作者信息

Zielinski T, Zeitter D, Müller S, Bartlett R R

机构信息

Department of Immunology, University of Mainz, Germany.

出版信息

Inflamm Res. 1995 Aug;44 Suppl 2:S207-8. doi: 10.1007/BF01778336.

DOI:10.1007/BF01778336
PMID:8548402
Abstract
摘要

相似文献

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Leflunomide, a reversible inhibitor of pyrimidine biosynthesis?
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The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis.免疫抑制剂来氟米特通过抑制嘧啶生物合成来抑制淋巴细胞增殖。
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Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide.免疫抑制剂来氟米特对二氢乳清酸脱氢酶的抑制作用。
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Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation.从头嘧啶生物合成的限制抑制Th1细胞活化并促进Th2细胞分化。
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Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide.来氟米特对透明质酸合酶（HAS）的影响：来氟米特对白细胞介素-1诱导的HAS1转录的非核因子κB依赖性抑制作用。
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The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis.

本文引用的文献

1
Effects of leflunomide (HWA 486) on expression of lymphocyte activation markers.来氟米特（HWA 486）对淋巴细胞活化标志物表达的影响。
Agents Actions. 1993;38 Spec No:C80-2. doi: 10.1007/BF01991144.
2
Leflunomide and cyclosporin-A prolong fish-to-mouse islet xenograft survival in BALB/C mice.
Transplant Proc. 1994 Jun;26(3):1310.
3
Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism.人类T淋巴细胞中的嘌呤和嘧啶代谢。脱氧核糖核苷酸代谢的调节。
Prp16p的哺乳动物同源物在对来氟米特耐受的细胞系中过表达，来氟米特是一种对类风湿关节炎有效的新型免疫调节药物。
RNA. 1998 Aug;4(8):1007-18. doi: 10.1017/s1355838298980554.
4
Leflunomide, a novel immunomodulating drug, inhibits homotypic adhesion of peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis.来氟米特是一种新型免疫调节药物，可抑制类风湿关节炎患者外周血和滑液单核细胞的同种型黏附。
Inflamm Res. 1996 Nov;45(11):550-6. doi: 10.1007/BF02342226.
5
Immunomodulation of rat antigen-induced arthritis by leflunomide alone and in combination with cyclosporin A.来氟米特单独及与环孢素A联合应用对大鼠抗原诱导性关节炎的免疫调节作用
Inflamm Res. 1996 Feb;45(2):103-7. doi: 10.1007/BF02265123.
J Biol Chem. 1983 Oct 25;258(20):12334-40.
4
Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture.癌细胞的生化策略与化疗设计：G. H. A. 克劳斯纪念讲座
Cancer Res. 1983 Aug;43(8):3466-92.
5
Prevention of kidney and skin graft rejection in rats by leflunomide, a new immunomodulating agent.新型免疫调节剂来氟米特对大鼠肾和皮肤移植排斥反应的预防作用
Transplant Proc. 1991 Feb;23(1 Pt 2):1083-6.
6
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).腺苷脱氨酶缺乏症和嘌呤核苷磷酸化酶缺乏症中的淋巴细胞特异性毒性：核苷激酶的可能作用。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5677-81. doi: 10.1073/pnas.74.12.5677.