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Secretion of human monocyte mature IL-1 beta: optimization of culture conditions and inhibition by ICE inhibitors.

作者信息

Uhl J, Krasney P, Brophy L, Arnold R, Dolle R, Helaszek C, Miller R, Gilman S, Ator M

机构信息

Department of Inflammation, Sterling Winthrop, Collegeville, PA 19426, USA.

出版信息

Inflamm Res. 1995 Aug;44 Suppl 2:S211-2. doi: 10.1007/BF01778338.

DOI:10.1007/BF01778338
PMID:8548404
Abstract
摘要

相似文献

1
Secretion of human monocyte mature IL-1 beta: optimization of culture conditions and inhibition by ICE inhibitors.
Inflamm Res. 1995 Aug;44 Suppl 2:S211-2. doi: 10.1007/BF01778338.
2
The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy.通过免疫电子显微镜观察,白细胞介素-1β转化酶(ICE)定位于人单核细胞的细胞外表面膜和细胞质基质中。
J Exp Med. 1995 Nov 1;182(5):1447-59. doi: 10.1084/jem.182.5.1447.
3
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock.白细胞介素-1β转换酶缺陷的小鼠在成熟白细胞介素-1β的产生方面存在缺陷,并且对内毒素休克具有抗性。
Cell. 1995 Feb 10;80(3):401-11. doi: 10.1016/0092-8674(95)90490-5.
4
Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells.
Blood. 1998 Jan 15;91(2):577-84.
5
Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease.健康及炎症性肠病状态下肠道巨噬细胞中白细胞介素1β及白细胞介素1β转换酶的表达
Gut. 1998 Feb;42(2):214-9. doi: 10.1136/gut.42.2.214.
6
A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo.白细胞介素-1β转换酶的一种合成抑制剂在体外和体内均可阻止内毒素诱导的白细胞介素-1β产生。
J Interferon Cytokine Res. 1995 Mar;15(3):243-8. doi: 10.1089/jir.1995.15.243.
7
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.白细胞介素-1β转化酶缺陷小鼠中细胞因子分泌和细胞凋亡的改变
Science. 1995 Mar 31;267(5206):2000-3. doi: 10.1126/science.7535475.
8
Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme.白细胞介素-1β转化酶抑制剂WIN 67694对小鼠巨噬细胞中成熟白细胞介素-1β产生及小鼠炎症模型的抑制作用。
J Immunol. 1995 Feb 1;154(3):1331-8.
9
Role of interleukin-1 beta converting enzyme (ICE) in leukemia.白细胞介素-1β转化酶(ICE)在白血病中的作用。
Cytokines Mol Ther. 1996 Mar;2(1):1-11.
10
Use of monoclonal antibodies to study interleukin-1 beta-converting enzyme expression: only precursor forms are detected in interleukin-1 beta-secreting cells.使用单克隆抗体研究白细胞介素-1β转化酶的表达:在分泌白细胞介素-1β的细胞中仅检测到前体形式。
Eur J Immunol. 1996 May;26(5):1032-42. doi: 10.1002/eji.1830260512.

引用本文的文献

1
Increased expression of IL-1beta converting enzyme in hippocampus after ischemia: selective localization in microglia.缺血后海马中白细胞介素-1β转化酶表达增加:在小胶质细胞中的选择性定位。
J Neurosci. 1996 Jul 1;16(13):4146-54. doi: 10.1523/JNEUROSCI.16-13-04146.1996.

本文引用的文献

1
P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme.基于天冬氨酸的肽α-((2,6-二氯苯甲酰基)氧基)甲基酮作为白细胞介素-1β转化酶的有效时间依赖性抑制剂。
J Med Chem. 1994 Mar 4;37(5):563-4. doi: 10.1021/jm00031a003.
2
The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta.活化单核细胞分泌白细胞介素-1的动力学。白细胞介素-1α与白细胞介素-1β之间的差异。
J Biol Chem. 1988 Jun 15;263(17):8473-9.
3
Identification of a monocyte specific pre-interleukin 1 beta convertase activity.
单核细胞特异性白细胞介素-1β前体转化酶活性的鉴定。
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5227-31. doi: 10.1073/pnas.86.14.5227.
4
Identification of IL-1 receptors on human monocytes.人类单核细胞上白细胞介素-1受体的鉴定。
J Immunol. 1989 Mar 1;142(5):1576-81.
5
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.单核细胞中白细胞介素-1β的加工需要一种新型异二聚体半胱氨酸蛋白酶。
Nature. 1992 Apr 30;356(6372):768-74. doi: 10.1038/356768a0.