报春花中的2-甲氧基-6-戊基-1,4-二羟基苯（米可尼丁）：一种可能的过敏原？

2-methoxy-6-pentyl-1,4-dihydroxybenzene (miconidin) from Primula obconica: a possible allergen?

作者信息

Krebs M, Christensen L P

机构信息

Department of Ornamentals, Research Center Arsley, Danish Institute of Plant and Soil Science, Arslev, Denmark.

出版信息

Contact Dermatitis. 1995 Aug;33(2):90-3. doi: 10.1111/j.1600-0536.1995.tb00507.x.

DOI:10.1111/j.1600-0536.1995.tb00507.x

PMID:8549150

Abstract

Miconidin (2-methoxy-6-pentyl-1,4-dihydroxybenzene) and the allergen primin (2-methoxy-6-pentyl-1,4-benzoquinone) have been isolated from fresh unchopped plant material (leaves, stems and flowers together) of Primula obconica. Miconidin and primin were obtained in approximately equal amounts and their structures determined by NMR and GC-MS. Miconidin, which is biogenetically related to primin, has not previously been isolated from Primula species, and the possibility that miconidin is an allergen in P. obconica is discussed.

摘要

米可尼丁（2-甲氧基-6-戊基-1,4-二羟基苯）和过敏原樱草素（2-甲氧基-6-戊基-1,4-苯醌）已从报春花新鲜未切碎的植物材料（叶、茎和花混合）中分离出来。米可尼丁和樱草素的产量大致相等，并通过核磁共振和气相色谱-质谱联用仪确定了它们的结构。米可尼丁与樱草素在生源上相关，此前尚未从报春花属植物中分离得到，本文还讨论了米可尼丁是否是报春花的过敏原。