Lew D P, Waldvogel F A
Division of Infectious Disease, Geneva University Hospital, Switzerland.
Drugs. 1995;49 Suppl 2:100-11. doi: 10.2165/00003495-199500492-00016.
The present review provides a critical quantitative analysis of the use of quinolones in osteomyelitis. Only papers published in peer-reviewed journals and related to the following areas were selected: experimental osteomyelitis, penetration of quinolones into human bone and clinical use in comparative and non-comparative studies. Cumulated results show clinical success rates of more than 90% in osteomyelitis caused by Enterobacteriaceae, after prolonged oral use of ciprofloxacin. However, further comparative studies using oral quinolones as single agents or in combination (versus standard parenteral therapy) are required in osteomyelitis due to S. aureus or P. aeruginosa, or in more complicated situations such as diabetic osteomyelitis or foreign body infection.
本综述对喹诺酮类药物在骨髓炎治疗中的应用进行了严谨的定量分析。仅选取了发表在同行评审期刊上且涉及以下领域的论文：实验性骨髓炎、喹诺酮类药物在人体骨骼中的渗透情况以及在比较性和非比较性研究中的临床应用。累积结果表明，长期口服环丙沙星后，由肠杆菌科细菌引起的骨髓炎临床成功率超过90%。然而，对于由金黄色葡萄球菌或铜绿假单胞菌引起的骨髓炎，或在糖尿病性骨髓炎或异物感染等更复杂的情况下，仍需要进一步开展使用口服喹诺酮类药物单药或联合用药（与标准肠外治疗相比）的比较性研究。
