乳酸聚合物作为氟喹诺酮类药物的可生物降解载体：一项体外研究。
Lactic acid polymers as biodegradable carriers of fluoroquinolones: an in vitro study.
作者信息
Kanellakopoulou K, Kolia M, Anastassiadis A, Korakis T, Giamarellos-Bourboulis E J, Andreopoulos A, Dounis E, Giamarellou H
机构信息
Fourth Department of Internal Medicine, Athens Medical School, Sismanoglion General Hospital, Greece.
出版信息
Antimicrob Agents Chemother. 1999 Mar;43(3):714-6. doi: 10.1128/AAC.43.3.714.
Abstract
A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.
摘要
描述了一种DL-丙交酯的可生物降解聚合物，它能促进环丙沙星或培氟沙星以超过慢性骨髓炎致病微生物最低抑菌浓度的水平释放。发现释放的持续时间和峰值取决于聚合物的分子量。其特性使其在治疗慢性骨感染方面具有前景。
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