Karaloglu D, Yasasever V, Ertürk N, Dalay N
I.U. Oncology Institute, Department of Basic Oncology Istanbul, Turkey.
Eur J Gynaecol Oncol. 1995;16(5):363-7.
The serum concentration of the cell proliferation marker TPS (Tissue Polypeptide-Specific Antigen) was compared with 7 different common tumor markers (CEA, CA 12-5, CA 19-9, CA 15-3, ferritin, AFP and beta 2-Microglobulin) in order to assess its practical value in the management of breast cancer. The new monoclonal TPS assay utilizing the specific epitope M3 is used to monitor cell multiplication in cancer patients. The values are not related to tumor burden but rather reflect the tumor proliferation rate. In our study no association was found between the TPS values and the age of the patients and histologic tumor types. Significant correlation was observed between the TPS values and the menopausal status of the patient. The regression analyses between TPS and the other markers did not reveal a correlation. Association between the TPS values and the CA 15-3 was not found. However, strong correlation between CA 15-3 and four other markers was observed. Therefore, it was concluded that TPS can provide additional information when used in combination with CA 15-3.
为评估细胞增殖标志物TPS（组织多肽特异性抗原）在乳腺癌管理中的实用价值，将其血清浓度与7种不同的常见肿瘤标志物（癌胚抗原、癌抗原125、癌抗原199、癌抗原153、铁蛋白、甲胎蛋白和β2微球蛋白）进行了比较。利用特异性表位M3的新型单克隆TPS检测法用于监测癌症患者的细胞增殖。这些值与肿瘤负荷无关，而是反映肿瘤增殖率。在我们的研究中，未发现TPS值与患者年龄及肿瘤组织学类型之间存在关联。观察到TPS值与患者绝经状态之间存在显著相关性。TPS与其他标志物之间的回归分析未显示出相关性。未发现TPS值与癌抗原153之间存在关联。然而，观察到癌抗原153与其他四种标志物之间存在强相关性。因此，得出结论，TPS与癌抗原153联合使用时可提供额外信息。
