Eskelinen M, Kataja V, Hämäläinen E, Kosma V M, Penttilä I, Alhava E
Department of Surgery, University and University Hospital of Kuopio, Finland.
Anticancer Res. 1997 Mar-Apr;17(2B):1231-4.
The aim of the present study was to assess the clinical value of five serum tumour markers AFP, CA 15-3, CEA, TPS and Neu oncoprotein (p 185) in the diagnosis of breast cancer. The serum values were measured in a prospective series of patients with breast cancer (n = 233), benign breast disease (n = 176) and healthy control subjects (n = 215). The cut-off levels (90% specificity) were determined for each test. Using these cut-off levels the diagnostic sensitivity of the CEA test was 0.23, for the AFP test it was 0.16, for the CA 15-3 test 0.27, for the TPS test 0.18 and for the Neu oncoprotein test 0.19 in detecting breast cancer. Correlation coefficients (Pearson's) were statistically significant between CEA and CA 15-3, and between CA 15-3 and Neu oncoprotein measurements in breast cancer patients. In patients with benign breast disease the serum levels of AFP, CA 15-3, CEA and TPS correlated with age, being somewhat higher in older patients. Similarly, in population controls higher age correlated with higher levels of AFP, CA 15-3, Neu and TPS. In breast cancer patients there was no correlation between the age at diagnosis and any of the measured markers. The only marker statistically significantly associated with the stage of breast cancer was CA 15-3. In conclusion, our results indicate that serum CEA, AFP, CA 15-3, TPS and Neu oncoprotein are only of limited value in the diagnosis of breast cancer.
本研究的目的是评估五种血清肿瘤标志物甲胎蛋白（AFP）、癌抗原15-3（CA 15-3）、癌胚抗原（CEA）、组织多肽特异性抗原（TPS）和神经肿瘤蛋白（p 185）在乳腺癌诊断中的临床价值。对一系列前瞻性乳腺癌患者（n = 233）、乳腺良性疾病患者（n = 176）和健康对照者（n = 215）测定了血清值。确定了每项检测的临界值（特异性90%）。使用这些临界值，CEA检测在检测乳腺癌时的诊断敏感性为0.23，AFP检测为0.16，CA 15-3检测为0.27，TPS检测为0.18，神经肿瘤蛋白检测为0.19。在乳腺癌患者中，CEA与CA 15-3之间以及CA 15-3与神经肿瘤蛋白测量值之间的相关系数（Pearson相关性）具有统计学意义。在乳腺良性疾病患者中，AFP、CA 15-3、CEA和TPS的血清水平与年龄相关，老年患者的水平略高。同样，在人群对照中，年龄越大，AFP、CA 15-3、神经肿瘤蛋白和TPS的水平越高。在乳腺癌患者中，诊断时的年龄与任何测量的标志物之间均无相关性。唯一与乳腺癌分期有统计学显著相关性的标志物是CA 15-3。总之，我们的结果表明，血清CEA、AFP、CA 15-3、TPS和神经肿瘤蛋白在乳腺癌诊断中的价值有限。
