Goldberg G S, Moreno A P, Bechberger J F, Hearn S S, Shivers R R, MacPhee D J, Zhang Y C, Naus C C
Department of Anatomy, University of Western Ontario, London, Canada.
Exp Cell Res. 1996 Jan 10;222(1):48-53. doi: 10.1006/excr.1996.0006.
Glycyrrhetinic acid exhibits many pharmacological activities, including the ability to block gap junctional communication. However, the mechanism of glycyrrhetinic action is not clear. Others have shown that glycyrrhetinic acid apparently binds to a single proteinatious binding site in the plasma membrane. We present evidence that while exposure to glycyrrhetinic acid derivatives may not affect protein synthesis or location, it does seem to alter connexon particle packing in gap junction plaques.
