Singh N, Shukla M M, Srivastava R, Sharma V P
Malaria Research Centre (Field Station), Jabalpur, India.
Indian J Malariol. 1995 Mar;32(1):6-13.
In the study period of two years 145 pregnant and 79 non-pregnant women with malarial infection were recorded. Plasmodium falciparum was the most prevalent species accounting for 72% of the total malaria infection in pregnant women while, in non-pregnant women it accounted for 58%. Results were analysed according to the species to which the parasite belonged, period of gestation and parity. While cerebral malaria, abortions, intrauterine foetal death, maternal anaemia were common in pregnant patients, only one neonatal death was recorded. Malaria parasites were not found in infants born to mothers with very heavy parasitaemia at the time of delivery. Even though pregnant women of all age groups and parity remain highly susceptible to malaria throughout pregnancy and puerperium from this area, some striking differences like malaria infection more prevalent in primigravidas than multigravidas and in second trimester than in third trimester were noticed in comparison to northern India. Results emphasize the need to target malaria control for this group of women. Failure to clear parasitaemia after chloroquine administration in P. falciparum was common in both pregnant and non-pregnant women. This is an area, where there is a great need to introduce effective malaria interventions. As chloroquine resistant parasites spread a better understanding of the problem is needed leading to a few chemotherapeutic options for pregnant women.
在为期两年的研究期间，记录了145名感染疟疾的孕妇和79名感染疟疾的非孕妇。恶性疟原虫是最常见的种类，占孕妇疟疾感染总数的72%，而在非孕妇中占58%。根据寄生虫所属种类、妊娠期和产次对结果进行了分析。虽然脑型疟疾、流产、宫内胎儿死亡、孕产妇贫血在孕妇中很常见，但仅记录到1例新生儿死亡。在分娩时患有非常严重寄生虫血症的母亲所生的婴儿中未发现疟原虫。尽管该地区所有年龄组和产次的孕妇在整个孕期和产褥期仍然极易感染疟疾，但与印度北部相比，发现了一些显著差异，如初产妇的疟疾感染比经产妇更普遍，妊娠中期比妊娠晚期更普遍。结果强调了针对这组妇女进行疟疾控制的必要性。在恶性疟原虫感染的孕妇和非孕妇中，服用氯喹后未能清除寄生虫血症的情况很常见。这是一个非常需要引入有效的疟疾干预措施的领域。随着耐氯喹寄生虫的传播，需要更好地了解这一问题，从而为孕妇提供一些化疗选择。
