Ohkusa T, Ozaki Y, Sato C, Mikuni K, Ikeda H
First Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Japan.
Digestion. 1995;56(5):415-20. doi: 10.1159/000201269.
We investigated the influence of lactosucrose on the intestinal flora of healthy volunteers. Eight healthy volunteers (male:female = 4:4, age 34 +/- 4 years) received 6 g of lactosucrose daily for 8 weeks. Fecal microflora, bacterial metabolites, pH, and moisture were analyzed before and after the administration of lactosucrose. The results showed that the number and percentage of Bifidobacterium sp. in relation to the total bacteria significantly increased during the period of lactosucrose administration. Although fecal putrefactive products, fatty acids, pH, moisture content, and stool volume did not show significant changes during the test period, the amount of fecal phenol showed a negative correlation with the number of Bifidobacterium sp. Fecal ammonia significantly decreased after 4 and 8 weeks of lactosucrose administration, and 1 week after the end of lactosucrose administration, compared with results after a 1-week administration of lactosucrose. When the administration was stopped, the percentage of Bifidobacterium sp. in relation to the total count gradually decreased to the same level as before the administration of lactosucrose. These results suggest that under physiological conditions, lactosucrose acts on the intestinal microflora as a growth factor of Bifidobacterium sp.
我们研究了乳糖蔗糖对健康志愿者肠道菌群的影响。八名健康志愿者（男：女 = 4：4，年龄34±4岁）连续8周每天服用6克乳糖蔗糖。在服用乳糖蔗糖前后对粪便微生物群、细菌代谢产物、pH值和水分进行了分析。结果表明，在服用乳糖蔗糖期间，双歧杆菌属相对于总细菌的数量和百分比显著增加。虽然在试验期间粪便腐败产物、脂肪酸、pH值、水分含量和粪便体积没有显著变化，但粪便酚的量与双歧杆菌属的数量呈负相关。与服用乳糖蔗糖1周后的结果相比，服用乳糖蔗糖4周和8周后以及停止服用乳糖蔗糖1周后，粪便氨显著降低。当停止给药时，双歧杆菌属相对于总数的百分比逐渐降至与服用乳糖蔗糖前相同的水平。这些结果表明，在生理条件下，乳糖蔗糖作为双歧杆菌属的生长因子作用于肠道微生物群。
