Das A, Chaudhuri S K
Department of Physiology, Medical College, Calcutta.
Indian J Physiol Pharmacol. 1995 Jul;39(3):223-30.
Concentrations of some neurotransmitters, viz. noradrenaline (NA), 5-hydroxytryptamine (5-HT), dopamine (DA), histamine (H) and gamma aminobutyric acid (GABA) in a part of brain consisting of medulla, pons, mid brain, thalamus and hypothalamus were measured in ovariectomized (OVx), intact (+Te) and castrated male (Tex) rats both without injecting estrogen (E) or E and progesterone (P) as well as after E and E+P administration. Some effects, (which, as far as we are aware of) have not been previously reported, were noted (in addition to other already documented observations). These include: (i) castration in males causes a fall of the level of GABA, NA, 5-HT and DA, (ii) E therapy also causes fall of the levels of GABA, NA and 5-HT and thus E therapy produces similar results like those of bilateral orchidectomy, (iii) P therapy not only reverses the fall of (GABA) but raises it more than the normal value, (iv) P therapy, it appears (although faintly), retrieve to some extent the fall of NA level due to E therapy, (v) Like the OVx rats, castrated as well as intact rats also showed a fall in the 5-HT level with E treatment but showed a rise when treated by E followed by P, (vi) In between the castrated males and castrated females, the concentrations of all these brain neurotransmitters differ. The probable significances have been discussed.
在去卵巢（OVx）、完整（+Te）和去势雄性（Tex）大鼠中，测量了由延髓、脑桥、中脑、丘脑和下丘脑组成的部分脑区中一些神经递质的浓度，这些大鼠均未注射雌激素（E）或E和孕酮（P），以及在给予E和E+P之后。除了其他已记录的观察结果外，还注意到了一些（据我们所知）以前未报道过的效应。这些效应包括：（i）雄性去势导致GABA、NA、5-HT和DA水平下降，（ii）E治疗也导致GABA、NA和5-HT水平下降，因此E治疗产生的结果与双侧睾丸切除相似，（iii）P治疗不仅能逆转（GABA）水平的下降，还能使其升高超过正常值，（iv）P治疗似乎（尽管不太明显）在一定程度上缓解了E治疗导致的NA水平下降，（v）与OVx大鼠一样，去势和完整大鼠在接受E治疗时5-HT水平也会下降，但在接受E后再接受P治疗时会升高，（vi）在去势雄性和去势雌性之间，所有这些脑内神经递质的浓度存在差异。文中讨论了其可能的意义。
