Chaudhuri S K, Chattopadhyay R N, Maitra S K, Ray S, Chaudhuri S
Department of Physiology, Medical College, Calcutta.
Indian J Physiol Pharmacol. 1992 Oct;36(4):255-8.
Effects of progesterone on four neurotransmitters (viz, noradrenaline, 5-HT, dopamine and histamine) of brain were seen in rats with intact ovaries. It was found that progesterone lowers the noradrenaline concentration in medulla, pons, midbrain, hypothalamus, thalami and pituitary, uniformly, when the rats were killed within 4 hours of progesterone injection. At longer intervals (48 hrs) effects of progesterone were seen when progesterone in heavy dose was administered to rats pretreated with estrogen. It is likely that one of the modes of action of the oral contraceptives may be the reduction of noradrenaline content in selected areas of brain, by progesterone. It is also suggested, therapeutic usage of progesterone carries the risk of development of depression in the user.
在卵巢完整的大鼠中观察到孕酮对大脑中四种神经递质（即去甲肾上腺素、5-羟色胺、多巴胺和组胺）的影响。研究发现，当在注射孕酮后4小时内处死大鼠时，孕酮会使延髓、脑桥、中脑、下丘脑、丘脑和垂体中的去甲肾上腺素浓度均匀降低。当对用雌激素预处理的大鼠给予大剂量孕酮时，在更长的时间间隔（48小时）会观察到孕酮的作用。口服避孕药的作用方式之一可能是通过孕酮降低大脑特定区域的去甲肾上腺素含量。也有人提出，孕酮的治疗性使用会使使用者有患抑郁症的风险。
