Singh J, Kaur A H, Mathur S K
Department of Pharmacology, Medical College, Rohtak.
Indian J Physiol Pharmacol. 1995 Jul;39(3):275-8.
Liver necrosis was produced in rats by administering 3 doses o a mixture o carbon tetrachloide+olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels serun aspartate aminotrans ferase (AST), alanine aminotransferase (AIT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Nitrendipine, nimodipine and nisoldipine (1 mg/100 g of rat, ip) significantly reduced these elevated levels of AST, AIT and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in nitrendipine, nimodipine and nisoldipine pre-treated animals as observed macroscopically and histologically.
通过腹腔注射给予大鼠3剂（2 ml/kg）四氯化碳与橄榄油的混合物，造成大鼠肝坏死。血清天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和γ-谷氨酰转肽酶（γ-GT）水平升高以及肝脏切片的组织病理学观察结果均证实了肝脏损伤。尼群地平、尼莫地平和尼索地平（1 mg/100 g大鼠，腹腔注射）显著降低了AST、ALT和γ-GT的这些升高水平。从宏观和组织学观察发现，在尼群地平、尼莫地平和尼索地平预处理的动物中，四氯化碳诱导的肝坏死也显著减少。
