Gene modification via "plug and socket" gene targeting.
作者信息
Lewis J, Yang B, Detloff P, Smithies O
机构信息
University of North Carolina, Chapel Hill 27599, USA.
出版信息
J Clin Invest. 1996 Jan 1;97(1):3-5. doi: 10.1172/JCI118403.
Abstract
摘要
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Genetics. 1943 Nov;28(6):491-511. doi: 10.1093/genetics/28.6.491.
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Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy.胚胎干细胞中的定点突变：一种基因靶向标签交换策略。
Mol Cell Biol. 1993 Jul;13(7):4115-24. doi: 10.1128/mcb.13.7.4115-4124.1993.
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Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.利用双置换基因打靶技术在胚胎干细胞和小鼠中用人类α-乳白蛋白基因替换小鼠的α-乳白蛋白基因。
Mol Cell Biol. 1994 Feb;14(2):1009-16. doi: 10.1128/mcb.14.2.1009-1016.1994.
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Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.双置换：通过胚胎干细胞中的同源重组将微小突变有效引入小鼠Col1a-1基因的策略。
Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2819-23. doi: 10.1073/pnas.91.7.2819.
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Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy.通过“插头与插座”重复靶向策略对小鼠成年β-珠蛋白基因进行缺失和替换。
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