Ramoni C, Dupuis M L, Vecchia P, Polichetti A, Petrini C, Bersani F, Capri M, Cossarizza A, Franceschi C, Grandolfo M
Department of Immunology, Istituto Superiore di Sanità, Rome, Italy.
Int J Radiat Biol. 1995 Dec;68(6):693-705. doi: 10.1080/09553009514551711.
Epidemiological studies have suggested, but not demonstrated, a role of exposure to 50/60-Hz magnetic fields in increasing cancer risk in man (workers and the general population). A possible target of magnetic fields is the immune system. In particular, it is known that an important defence against cancer is represented by natural killer (NK) cells capable of killing cancer cell targets. To test this hypothesis, human NK cells, stimulated or not with phytohaemagglutinin or interleukin 2, were exposed to 50-Hz sinusoidal magnetic fields before or during the cytotoxicity test, and then mixed with a variety of target cancer cell lines (Daudi, Raji, U937, H14, IGROV, SW626, K562, HL60). The experiments were performed in two laboratories (Rome and Modena) by means of two different exposure systems. The results of both laboratories suggest that 50-Hz sinusoidal magnetic fields with flux densities up to 10 mT do not affect the cytotoxic activity of human NK cells.
流行病学研究表明，但未证实，暴露于50/60赫兹磁场在增加人类（工人和普通人群）患癌风险中所起的作用。磁场的一个可能靶点是免疫系统。特别是，众所周知，对癌症的一种重要防御由能够杀伤癌细胞靶点的自然杀伤（NK）细胞体现。为验证这一假设，在用植物血凝素或白细胞介素2刺激或未刺激的情况下，将人类NK细胞在细胞毒性测试前或测试期间暴露于50赫兹正弦磁场，然后与多种靶癌细胞系（Daudi、Raji、U937、H14、IGROV、SW626、K562、HL60）混合。实验在两个实验室（罗马和摩德纳）通过两种不同的暴露系统进行。两个实验室的结果均表明，磁通密度高达10毫特斯拉的50赫兹正弦磁场不会影响人类NK细胞的细胞毒性活性。
