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对出生后第一周接受重组人粒细胞集落刺激因子治疗的疑似败血症新生儿进行的两年随访。

A two-year follow-up of neonates with presumed sepsis treated with recombinant human granulocyte colony-stimulating factor during the first week of life.

作者信息

Rosenthal J, Healey T, Ellis R, Gillan E, Cairo M S

机构信息

Division of Hematology/Oncology, Children's Hospital of Orange County, Orange, California 92668, USA.

出版信息

J Pediatr. 1996 Jan;128(1):135-7. doi: 10.1016/s0022-3476(96)70443-2.

DOI:10.1016/s0022-3476(96)70443-2
PMID:8551404
Abstract

We have previously reported that recombinant human granulocyte colony-stimulating factor was well tolerated and resulted in sustained neutrophilia and improvement of neutrophil functions in newborn infants with presumed sepsis. We now report a 2-year follow-up on 21 of the initial cohort of 28 patients. Treatment with recombinant human granulocyte colony-stimulating factor in neonates with presumed sepsis was not associated with any long-term adverse hematologic, immunologic, or developmental effects.

摘要

我们之前曾报道，重组人粒细胞集落刺激因子耐受性良好，可使疑似脓毒症的新生儿持续出现中性粒细胞增多，并改善中性粒细胞功能。我们现在报告对最初28例患者中的21例进行的为期2年的随访结果。在疑似脓毒症的新生儿中使用重组人粒细胞集落刺激因子进行治疗，未发现有任何长期不良血液学、免疫学或发育方面的影响。

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1
A two-year follow-up of neonates with presumed sepsis treated with recombinant human granulocyte colony-stimulating factor during the first week of life.对出生后第一周接受重组人粒细胞集落刺激因子治疗的疑似败血症新生儿进行的两年随访。
J Pediatr. 1996 Jan;128(1):135-7. doi: 10.1016/s0022-3476(96)70443-2.
2
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引用本文的文献

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A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: childhood outcomes at 5 years.粒细胞巨噬细胞集落刺激因子治疗新生儿败血症的随机试验：5岁时的儿童期结局
Arch Dis Child Fetal Neonatal Ed. 2015 Jul;100(4):F320-6. doi: 10.1136/archdischild-2014-307410. Epub 2015 Apr 28.
2
Colony stimulating factors as adjunctive therapy in neonatal sepsis.集落刺激因子作为新生儿败血症的辅助治疗手段。
Indian J Pediatr. 2006 May;73(5):393-4. doi: 10.1007/BF02758558.
3
G-CSF and GM-CSF for treating or preventing neonatal infections.
用于治疗或预防新生儿感染的粒细胞集落刺激因子和粒细胞-巨噬细胞集落刺激因子。
Cochrane Database Syst Rev. 2003;2003(3):CD003066. doi: 10.1002/14651858.CD003066.
4
Colony-Stimulating Factors in the Therapeutic Approach to Sepsis.脓毒症治疗方法中的集落刺激因子
Curr Infect Dis Rep. 1999 Aug;1(3):218-223. doi: 10.1007/s11908-999-0022-6.
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Promising stratagems for reducing the burden of neonatal sepsis.减轻新生儿败血症负担的前景策略。
Arch Dis Child Fetal Neonatal Ed. 2000 Sep;83(2):F150-3. doi: 10.1136/fn.83.2.f150.
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Haemopoietic colony stimulating factors for preterm neonates.用于早产儿的造血集落刺激因子。
Arch Dis Child Fetal Neonatal Ed. 1997 Mar;76(2):F128-33. doi: 10.1136/fn.76.2.f128.