Legro R S, Laifer S A
Department of Obstetrics and Gynecology, M.S. Hershey Medical Center, Pennsylvania State University, Hershey 17033, USA.
J Reprod Med. 1995 Oct;40(10):689-95.
To determine the incidence and maternal-fetal outcome of first-trimester pancreatitis at one institution.
A retrospective study of pancreatitis presenting during the first trimester of pregnancy over a 10-year period at Magee Womens Hospital.
There were 11 cases, for an incidence of 0.1/1,000 live births. There was no maternal mortality. Three patients elected voluntary termination, and eight pregnancies proceeded to term. All delivered at > or = 35 weeks. The mean gestational age was 38.9 +/- 2.1 weeks (mean +/- SD), and mean birth weight was 3,103 +/- 641 g. There were no adverse neonatal outcomes, although one patient had a fetus with severe intrauterine growth retardation. Maternal morbidity and complications were due mainly to gallstone pancreatitis, which was the most commonly identified cause of pancreatitis, and three patients underwent cholecystectomy during pregnancy or the puerperium. No first-trimester pregnancy terminations were performed for medical indications. Pancreatitis tended to recur during the examined pregnancy (mean number of admissions, 2.27 +/- 2.1).
Patients should be advised of the relapsing nature of pancreatitis that presents during the first trimester. However, there is a good prognosis for pregnancy outcome.
确定某机构孕早期胰腺炎的发病率及母胎结局。
对 Magee 妇女医院 10 年间孕早期出现的胰腺炎进行回顾性研究。
共 11 例，发病率为 0.1/1000 活产。无孕产妇死亡。3 例患者选择自愿终止妊娠，8 例妊娠至足月。均在≥35 周分娩。平均孕周为 38.9±2.1 周（均值±标准差），平均出生体重为 3103±641g。尽管有 1 例患者的胎儿患有严重宫内生长受限，但无不良新生儿结局。孕产妇发病和并发症主要归因于胆石性胰腺炎，这是最常见的胰腺炎病因，3 例患者在孕期或产褥期接受了胆囊切除术。未因医学指征进行孕早期妊娠终止。在研究的妊娠期内胰腺炎有复发倾向（平均入院次数，2.27±2.1）。
应告知患者孕早期出现的胰腺炎具有复发特性。然而，妊娠结局预后良好。
