Tsai C C, Lin S D, Lai C S, Chou C K
Department of Surgery, Kaohsiung Medical College Hospital, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1995 Dec;11(12):673-7.
Necrotizing fasciitis is a severe and sometimes life-threatening soft tissue infection that is characterized by rapidly widespreading necrosis of fascia and subcutaneous tissue. Fifty-four cases of necrotizing fasciitis were reviewed over a 5-year period. Among them, 25 patients (46%) had diabetes mellitus. The majority of the wound bacterial cultures (71%) yielded a mixed growing. There were negative cultures in six patients, and single organism growth in 14 patients (29%). The predominant organisms growth were Streptococci, Staphylococci, and Escherichia coli. The overall mortality rate was 22% (12/54). Death was caused by systemic septic complications in these patients. All 12 mortalities resulted from delayed debridement (averaging 25 days after initial symptoms appeared). Our study indicates that the early recognition and prompt debridement of all necrotic tissue is essential for reducing the mortality rates of this potentially lethal condition.
坏死性筋膜炎是一种严重的、有时会危及生命的软组织感染，其特征是筋膜和皮下组织迅速广泛坏死。在5年期间对54例坏死性筋膜炎病例进行了回顾。其中，25例患者（46%）患有糖尿病。大多数伤口细菌培养（71%）显示混合生长。6例患者培养结果为阴性，14例患者（29%）为单一微生物生长。主要生长的微生物是链球菌、葡萄球菌和大肠杆菌。总死亡率为22%（12/54）。这些患者的死亡是由全身性脓毒症并发症引起的。所有12例死亡均因清创延迟（初始症状出现后平均25天）。我们的研究表明，早期识别并及时清除所有坏死组织对于降低这种潜在致命疾病的死亡率至关重要。
