[心房利钠肽（hANP）水平及精氨酸加压素（AVP）在老年夜尿症患者中的作用]

[Participation of atrial natriuretic peptide (hANP) levels and arginine vasopressin (AVP) in aged persons with nocturia].

作者信息

Kikuchi Y

机构信息

Department of Urology, Fukushima Medical College.

出版信息

Nihon Hinyokika Gakkai Zasshi. 1995 Nov;86(11):1651-9. doi: 10.5980/jpnjurol1989.86.1651.

DOI:10.5980/jpnjurol1989.86.1651

PMID:8551708

Abstract

BACKGROUND

The associations of human atrial natriuretic peptide (hANP) and arginine vasopressin (AVP) with nocturia in two groups of elderly individuals were investigated.

METHODS

Plasma hANP and AVP levels were determined at 8:00, 14:00, 20:00, 2:00 and 8:00 (2nd day) in 15 healthy younger elderly individuals and 30 elderly individuals who showed no abnormal physical findings. Urine volume, urinary Na and K levels, and urinary osomotic pressure were also determined every 6 hours at the above-mentioned times. The maximum diameter of the inferior vena cava (IVC) in the inferior portion of the confluence of the hepatic veins was determined at 14:00, 20:00 and 2:00 in 11 younger elderly individuals and 17 elderly individuals.

RESULTS

The mean hANP level was significantly higher in the elderly group than in the younger elderly group, and the mean AVP level was significantly higher in the younger elderly group than in the elderly group. There were no significant differences in diurnal variation in hANP between daytime and night among the younger elderly individuals, but the hANP level was significantly increased during the night in the elderly individuals. The AVP level was significantly higher at night than during the daytime in the younger elderly individuals, while it was significantly decreased at night in the elderly individuals. Although there was no marked diurnal variation in the IVC in any of the younger elderly individuals, IVC diameter was significantly increased at night in the elderly individuals. Urine volume was high during the daytime in the younger elderly group, and increased during the night in the elderly group.

CONCLUSIONS

The increase in body fluid and elevation of hANP over the time between evening and night, and the decrease in AVP accompanying these increases were considered to lead to the increase in urine volume during the night, and this increase is considered to be a factor in nocturia.

摘要

背景

研究了两组老年人中人类心房利钠肽（hANP）和精氨酸加压素（AVP）与夜尿症的关系。

方法

在15名健康的年轻老年人和30名无异常身体检查结果的老年人中，于8:00、14:00、20:00、2:00和8:00（第二天）测定血浆hANP和AVP水平。在上述时间每6小时还测定尿量、尿钠和钾水平以及尿渗透压。在11名年轻老年人和17名老年人中，于14:00、20:00和2:00测定肝静脉汇合处下方下腔静脉（IVC）的最大直径。

结果

老年组的平均hANP水平显著高于年轻老年组，年轻老年组的平均AVP水平显著高于老年组。年轻老年人白天和夜间hANP的昼夜变化无显著差异，但老年人夜间hANP水平显著升高。年轻老年人夜间的AVP水平显著高于白天，而老年人夜间的AVP水平显著降低。虽然年轻老年人中IVC均无明显的昼夜变化，但老年人夜间IVC直径显著增加。年轻老年组白天尿量高，老年组夜间尿量增加。