夜尿症和夜间多尿的健康老年人的利尿模式、血浆血管加压素和血压

Diuresis pattern, plasma vasopressin and blood pressure in healthy elderly persons with nocturia and nocturnal polyuria.

作者信息

Asplund R

机构信息

Family Medicine Stockholm, Karolinska Institute, Research and Development Unit, Sweden.

出版信息

Neth J Med. 2002 Aug;60(7):276-80.

PMID:12430573

Abstract

BACKGROUND

Nocturia, a common symptom in the elderly, is often caused by increased urine production at night.

METHODS

The present study comprised 17 men and six women aged 68.1 +/- 4.7 (mean +/- SD) years with nocturia (> or = 2 nocturnal voids) and nocturnal polyuria (nocturnal urinary output of > or = 0.9 mL min(-1)). A physical examination, measurements of recumbent blood pressure after a 15-minute rest, plasma AVP assay at noon and midnight, and urine collection performed during a 24-hour period.

RESULTS

The daytime urine output was 1358 +/- 664 mL, and the nocturnal urine output 796 +/- 312 mL. The AVP level was lower at midnight than at noon in 17 persons, and higher at midnight in six persons. Blood pressure was 142.0 +/- 15.7/87.4 +/- 9.1 mmHg. Systolic (but not diastolic) blood pressure increased with decreasing nocturnal plasma AVP. Increasing nocturnal diuresis rate (r2= 0.26; p < 0.01) but not plasma AVP was associated with increasing systolic blood pressure.

CONCLUSION

In elderly persons with nocturia and nocturnal polyuria, the plasma AVP is low and does not rise nocturnally. The systolic blood pressure is increased with increasing diuresis but unaffected by plasma AVP.

摘要

背景

夜尿症是老年人的常见症状，通常由夜间尿量增加引起。

方法

本研究纳入了17名男性和6名女性，年龄为68.1±4.7（平均±标准差）岁，患有夜尿症（夜间排尿≥2次）和夜间多尿症（夜间尿量≥0.9 mL·min⁻¹）。进行了体格检查、休息15分钟后的卧位血压测量、中午和午夜的血浆抗利尿激素（AVP）测定以及24小时尿液收集。

结果

白天尿量为1358±664 mL，夜间尿量为796±312 mL。17人午夜时的AVP水平低于中午，6人午夜时的AVP水平高于中午。血压为142.0±15.7/87.4±9.1 mmHg。收缩压（而非舒张压）随夜间血浆AVP降低而升高。夜间利尿率增加（r² = 0.26；p < 0.01）但血浆AVP未增加与收缩压升高相关。