Martins C, Fonseca I, Félix A, Roque L, Soares J
Departmento de Patologia Morfológica, Instituto Português de Oncologia de Francisco Gentil, Lisbon, Portugal.
J Surg Oncol. 1995 Dec;60(4):232-7. doi: 10.1002/jso.2930600404.
Cytogenic findings of 21 benign salivary gland tumors, including 14 pleomorphic adenomas, 5 Warthin's tumors, 1 myoepithelioma, and 1 cystadenoma, are reported. The present study confirms that pleomorphic adenomas characteristically have highly specific rearrangements involving only a few chromosome regions (3p21, 8q12 and 12q13-15) which suggests their specific role in the mixed tumor genesis. Warthin's tumors also show non-random numerical and structural alterations that were concurrent in one of the cases studied. To our knowledge no cytogenetic data are available in myoepitheliomas and cystadenomas. The former reveals a normal karyotype and the latter shows only clonal numerical alterations (gain of chromosomes 2 and 18).
报告了21例良性唾液腺肿瘤的细胞遗传学研究结果，其中包括14例多形性腺瘤、5例沃辛瘤、1例肌上皮瘤和1例囊腺瘤。本研究证实，多形性腺瘤具有特征性的高度特异性重排，仅涉及少数几个染色体区域（3p21、8q12和12q13 - 15），这表明它们在混合瘤发生中具有特定作用。沃辛瘤也显示出非随机的数量和结构改变，在所研究的一个病例中这些改变同时存在。据我们所知，关于肌上皮瘤和囊腺瘤尚无细胞遗传学数据。前者显示核型正常，后者仅显示克隆性数量改变（染色体2和18增多）。
