Nanas J N, Lolas C T, Charitos C E, Nanas S N, Margari Z J, Agapitos E V, Moulopoulos S D
University of Athens School of Medicine, Department of Clinical Therapeutics Alexandra Hospital, Greece.
J Thorac Cardiovasc Surg. 1996 Jan;111(1):55-61. doi: 10.1016/s0022-5223(96)70401-4.
The paraaortic counterpulsation device is a round pumping chamber with one valveless opening 20 mm in diameter and a 100 ml stroke volume. The paraaortic counterpulsation device was implanted on the ascending aorta of three male patients with intractable cardiogenic shock. Patients were assisted for 4 hours and 8 and 54 days, respectively; the first patient died as a result of nonresponding peripheral vasodilation and the other two died of septic shock. The two patients who were assisted for 8 and 54 days were conscious and able to function in a limited manner during the mechanical assistance. Discontinuation of the mechanical support for a few seconds was followed by low systolic arterial pressure (30 to 60 mm Hg) and syncopal episodes. Biochemical tests and autopsy results in these patients showed no evidence of blood cell destruction, thrombus formation, brain infarction, or other distal emboli. In conclusion, satisfactory hemodynamic effects, excellent biocompatibility, and simplicity of the implantation procedure in these patients encourage the use of the paraaortic counterpulsation device as a bridge to heart transplantation.
主动脉旁反搏装置是一个圆形的泵腔，有一个直径20毫米的无瓣开口，每搏输出量为100毫升。该主动脉旁反搏装置被植入三名患有顽固性心源性休克的男性患者的升主动脉。患者分别接受了4小时、8天和54天的辅助；第一名患者因外周血管扩张无反应而死亡，另外两名患者死于感染性休克。接受8天和54天辅助的两名患者在机械辅助期间意识清醒，能够有限地活动。停止机械支持几秒钟后，出现收缩期动脉压低（30至60毫米汞柱）和晕厥发作。这些患者的生化检查和尸检结果显示没有血细胞破坏、血栓形成、脑梗死或其他远端栓子的证据。总之，这些患者中令人满意的血流动力学效果、出色的生物相容性以及植入过程的简单性鼓励将主动脉旁反搏装置用作心脏移植的桥梁。
